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Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()

BACKGROUND: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region METHODS: Women ages 15–26 and 24–45 years from 5 regions were enr...

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Autores principales: Castellsagué, Xavier, Ault, Kevin A., Bosch, F. Xavier, Brown, Darron, Cuzick, Jack, Ferris, Daron G., Joura, Elmar A., Garland, Suzanne M., Giuliano, Anna R, Hernandez-Avila, Mauricio, Huh, Warner, Iversen, Ole-Erik, Kjaer, Susanne K., Luna, Joaquin, Monsonego, Joseph, Muñoz, Nubia, Myers, Evan, Paavonen, Jorma, Pitisuttihum, Punnee, Steben, Marc, Wheeler, Cosette M., Perez, Gonzalo, Saah, Alfred, Luxembourg, Alain, Sings, Heather L, Velicer, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886863/
https://www.ncbi.nlm.nih.gov/pubmed/29074187
http://dx.doi.org/10.1016/j.pvr.2016.03.002
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author Castellsagué, Xavier
Ault, Kevin A.
Bosch, F. Xavier
Brown, Darron
Cuzick, Jack
Ferris, Daron G.
Joura, Elmar A.
Garland, Suzanne M.
Giuliano, Anna R
Hernandez-Avila, Mauricio
Huh, Warner
Iversen, Ole-Erik
Kjaer, Susanne K.
Luna, Joaquin
Monsonego, Joseph
Muñoz, Nubia
Myers, Evan
Paavonen, Jorma
Pitisuttihum, Punnee
Steben, Marc
Wheeler, Cosette M.
Perez, Gonzalo
Saah, Alfred
Luxembourg, Alain
Sings, Heather L
Velicer, Christine
author_facet Castellsagué, Xavier
Ault, Kevin A.
Bosch, F. Xavier
Brown, Darron
Cuzick, Jack
Ferris, Daron G.
Joura, Elmar A.
Garland, Suzanne M.
Giuliano, Anna R
Hernandez-Avila, Mauricio
Huh, Warner
Iversen, Ole-Erik
Kjaer, Susanne K.
Luna, Joaquin
Monsonego, Joseph
Muñoz, Nubia
Myers, Evan
Paavonen, Jorma
Pitisuttihum, Punnee
Steben, Marc
Wheeler, Cosette M.
Perez, Gonzalo
Saah, Alfred
Luxembourg, Alain
Sings, Heather L
Velicer, Christine
author_sort Castellsagué, Xavier
collection PubMed
description BACKGROUND: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region METHODS: Women ages 15–26 and 24–45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. RESULTS: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81–85%). Types 31/33/45/52/58 accounted for 25–30% of CIN1 in Latin America and Europe, but 14–18% in North America and Asia. Types 31/33/45/52/58 accounted for 33–38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17–18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2–11% of CIN2/3. CONCLUSIONS: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3.
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spelling pubmed-58868632018-04-11 Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region() Castellsagué, Xavier Ault, Kevin A. Bosch, F. Xavier Brown, Darron Cuzick, Jack Ferris, Daron G. Joura, Elmar A. Garland, Suzanne M. Giuliano, Anna R Hernandez-Avila, Mauricio Huh, Warner Iversen, Ole-Erik Kjaer, Susanne K. Luna, Joaquin Monsonego, Joseph Muñoz, Nubia Myers, Evan Paavonen, Jorma Pitisuttihum, Punnee Steben, Marc Wheeler, Cosette M. Perez, Gonzalo Saah, Alfred Luxembourg, Alain Sings, Heather L Velicer, Christine Papillomavirus Res Article BACKGROUND: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region METHODS: Women ages 15–26 and 24–45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. RESULTS: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81–85%). Types 31/33/45/52/58 accounted for 25–30% of CIN1 in Latin America and Europe, but 14–18% in North America and Asia. Types 31/33/45/52/58 accounted for 33–38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17–18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2–11% of CIN2/3. CONCLUSIONS: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. Elsevier 2016-03-14 /pmc/articles/PMC5886863/ /pubmed/29074187 http://dx.doi.org/10.1016/j.pvr.2016.03.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Castellsagué, Xavier
Ault, Kevin A.
Bosch, F. Xavier
Brown, Darron
Cuzick, Jack
Ferris, Daron G.
Joura, Elmar A.
Garland, Suzanne M.
Giuliano, Anna R
Hernandez-Avila, Mauricio
Huh, Warner
Iversen, Ole-Erik
Kjaer, Susanne K.
Luna, Joaquin
Monsonego, Joseph
Muñoz, Nubia
Myers, Evan
Paavonen, Jorma
Pitisuttihum, Punnee
Steben, Marc
Wheeler, Cosette M.
Perez, Gonzalo
Saah, Alfred
Luxembourg, Alain
Sings, Heather L
Velicer, Christine
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title_full Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title_fullStr Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title_full_unstemmed Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title_short Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
title_sort human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886863/
https://www.ncbi.nlm.nih.gov/pubmed/29074187
http://dx.doi.org/10.1016/j.pvr.2016.03.002
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