Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss

OBJECTIVE: The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. RESULTS: During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy c...

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Autores principales: Sah, Anil Kumar, Shrestha, Nisha, Joshi, Pratikshya, Lakha, Renu, Shrestha, Sweta, Sharma, Laxmi, Chandra, Avinash, Singh, Neetu, KC, Yuvraj, Rijal, Bhola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887178/
https://www.ncbi.nlm.nih.gov/pubmed/29622028
http://dx.doi.org/10.1186/s13104-018-3321-x
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author Sah, Anil Kumar
Shrestha, Nisha
Joshi, Pratikshya
Lakha, Renu
Shrestha, Sweta
Sharma, Laxmi
Chandra, Avinash
Singh, Neetu
KC, Yuvraj
Rijal, Bhola
author_facet Sah, Anil Kumar
Shrestha, Nisha
Joshi, Pratikshya
Lakha, Renu
Shrestha, Sweta
Sharma, Laxmi
Chandra, Avinash
Singh, Neetu
KC, Yuvraj
Rijal, Bhola
author_sort Sah, Anil Kumar
collection PubMed
description OBJECTIVE: The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. RESULTS: During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0.05) and menstrual history (p > 0.05). However, significant association was seen between MTHFR C677T polymorphism and number of losses (p < 0.05), concluding that the risk of the polymorphism increased with the increase in number of losses. Significant variation in the MTHFR C677T genotype with number of losses among RPL couples were seen but not with other study variables. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3321-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-58871782018-04-09 Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss Sah, Anil Kumar Shrestha, Nisha Joshi, Pratikshya Lakha, Renu Shrestha, Sweta Sharma, Laxmi Chandra, Avinash Singh, Neetu KC, Yuvraj Rijal, Bhola BMC Res Notes Research Note OBJECTIVE: The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. RESULTS: During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0.05) and menstrual history (p > 0.05). However, significant association was seen between MTHFR C677T polymorphism and number of losses (p < 0.05), concluding that the risk of the polymorphism increased with the increase in number of losses. Significant variation in the MTHFR C677T genotype with number of losses among RPL couples were seen but not with other study variables. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3321-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-05 /pmc/articles/PMC5887178/ /pubmed/29622028 http://dx.doi.org/10.1186/s13104-018-3321-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Sah, Anil Kumar
Shrestha, Nisha
Joshi, Pratikshya
Lakha, Renu
Shrestha, Sweta
Sharma, Laxmi
Chandra, Avinash
Singh, Neetu
KC, Yuvraj
Rijal, Bhola
Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title_full Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title_fullStr Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title_full_unstemmed Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title_short Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
title_sort association of parental methylenetetrahydrofolate reductase (mthfr) c677t gene polymorphism in couples with unexplained recurrent pregnancy loss
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887178/
https://www.ncbi.nlm.nih.gov/pubmed/29622028
http://dx.doi.org/10.1186/s13104-018-3321-x
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