Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

UHRF1 plays multiple roles in regulating DNMT1-mediated DNA methylation maintenance during DNA replication. The UHRF1 C-terminal RING finger functions as an ubiquitin E3 ligase to establish histone H3 ubiquitination at Lys18 and/or Lys23, which is subsequently recognized by DNMT1 to promote its loca...

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Detalles Bibliográficos
Autores principales: Li, Tao, Wang, Linsheng, Du, Yongming, Xie, Si, Yang, Xi, Lian, Fuming, Zhou, Zhongjun, Qian, Chengmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887372/
https://www.ncbi.nlm.nih.gov/pubmed/29471350
http://dx.doi.org/10.1093/nar/gky104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887372/
https://www.ncbi.nlm.nih.gov/pubmed/29471350
http://dx.doi.org/10.1093/nar/gky104

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