An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3 signaling, conferring an oncogenic dependence, which we studied here. We discovered a positive feedback loop, in which the activation of p38 an...

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Detalles Bibliográficos
Autores principales: Mahe, Mélanie, Dufour, Florent, Neyret‐Kahn, Hélène, Moreno‐Vega, Aura, Beraud, Claire, Shi, Mingjun, Hamaidi, Imene, Sanchez‐Quiles, Virginia, Krucker, Clementine, Dorland‐Galliot, Marion, Chapeaublanc, Elodie, Nicolle, Remy, Lang, Hervé, Pouponnot, Celio, Massfelder, Thierry, Radvanyi, François, Bernard‐Pierrot, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887543/
https://www.ncbi.nlm.nih.gov/pubmed/29463565
http://dx.doi.org/10.15252/emmm.201708163

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