The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study

The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG and a control group of 52 healthy individuals were recruited from the First Opht...

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Autores principales: KARMIRIS, Efthymios, KOURTIS, Nikos, P. PANTOU, Malena, DEGIANNIS, Dimitris, GEORGALAS, Ilias, PAPACONSTANTINOU, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Hypothesis, Discovery & Innovation Ophthalmology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887604/
https://www.ncbi.nlm.nih.gov/pubmed/29644242
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author KARMIRIS, Efthymios
KOURTIS, Nikos
P. PANTOU, Malena
DEGIANNIS, Dimitris
GEORGALAS, Ilias
PAPACONSTANTINOU, Dimitrios
author_facet KARMIRIS, Efthymios
KOURTIS, Nikos
P. PANTOU, Malena
DEGIANNIS, Dimitris
GEORGALAS, Ilias
PAPACONSTANTINOU, Dimitrios
author_sort KARMIRIS, Efthymios
collection PubMed
description The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG and a control group of 52 healthy individuals were recruited from the First Ophthalmology Department of Athens University. DNA was isolated from whole blood samples and genotype frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were assessed. Genotype distribution frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were not statistically different between patients with POAG and control subjects. The present study failed to determine any significant genotypic association with POAG, despite the fact that the presence of the C allele was scarcely increased in the POAG when compared with the control group.
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spelling pubmed-58876042018-04-11 The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study KARMIRIS, Efthymios KOURTIS, Nikos P. PANTOU, Malena DEGIANNIS, Dimitris GEORGALAS, Ilias PAPACONSTANTINOU, Dimitrios Med Hypothesis Discov Innov Ophthalmol Original Article The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG and a control group of 52 healthy individuals were recruited from the First Ophthalmology Department of Athens University. DNA was isolated from whole blood samples and genotype frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were assessed. Genotype distribution frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were not statistically different between patients with POAG and control subjects. The present study failed to determine any significant genotypic association with POAG, despite the fact that the presence of the C allele was scarcely increased in the POAG when compared with the control group. Medical Hypothesis, Discovery & Innovation Ophthalmology 2018 /pmc/articles/PMC5887604/ /pubmed/29644242 Text en ©2018, Med Hypothesis Discov Innov Ophthalmol. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 License (CC BY-NC 3.0) (https://creativecommons.org/licenses/by-nc/3.0/) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
KARMIRIS, Efthymios
KOURTIS, Nikos
P. PANTOU, Malena
DEGIANNIS, Dimitris
GEORGALAS, Ilias
PAPACONSTANTINOU, Dimitrios
The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title_full The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title_fullStr The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title_full_unstemmed The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title_short The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study
title_sort association between tgf-β1 g915c (arg25pro) polymorphism and the development of primary open angle glaucoma: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887604/
https://www.ncbi.nlm.nih.gov/pubmed/29644242
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