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22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH
Overall Abstract: Implications of a heterogeneous clinical syndrome such as schizophrenia have long been known but little attended. Fundamental problems persist, such as schizophrenia as the phenotype in GWAS studies. But the 21(st) Century has brought substantial attention to limitations in acquisi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887607/ http://dx.doi.org/10.1093/schbul/sby014.089 |
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author | Carpenter, William T |
author_facet | Carpenter, William T |
author_sort | Carpenter, William T |
collection | PubMed |
description | Overall Abstract: Implications of a heterogeneous clinical syndrome such as schizophrenia have long been known but little attended. Fundamental problems persist, such as schizophrenia as the phenotype in GWAS studies. But the 21(st) Century has brought substantial attention to limitations in acquisition of new knowledge. New concepts and methods are being implemented. Selected examples will be reviewed and potential scientific advances that influence clinical care will be outlined. This will include advances in mechanism knowledge, identification of novel targets for therapeutic discovery, re-conceptualization of psychopathology for regulatory purposes, a new integration of behavioral and biological science to inform nosology, enhanced testing of neural circuit hypotheses, and serious attention to primary prevention. |
format | Online Article Text |
id | pubmed-5887607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58876072018-04-11 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH Carpenter, William T Schizophr Bull Abstracts Overall Abstract: Implications of a heterogeneous clinical syndrome such as schizophrenia have long been known but little attended. Fundamental problems persist, such as schizophrenia as the phenotype in GWAS studies. But the 21(st) Century has brought substantial attention to limitations in acquisition of new knowledge. New concepts and methods are being implemented. Selected examples will be reviewed and potential scientific advances that influence clinical care will be outlined. This will include advances in mechanism knowledge, identification of novel targets for therapeutic discovery, re-conceptualization of psychopathology for regulatory purposes, a new integration of behavioral and biological science to inform nosology, enhanced testing of neural circuit hypotheses, and serious attention to primary prevention. Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5887607/ http://dx.doi.org/10.1093/schbul/sby014.089 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Carpenter, William T 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title | 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title_full | 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title_fullStr | 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title_full_unstemmed | 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title_short | 22. THE NEAR FUTURE FOR SCHIZOPHRENIA (PSYCHOSIS) RESEARCH |
title_sort | 22. the near future for schizophrenia (psychosis) research |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887607/ http://dx.doi.org/10.1093/schbul/sby014.089 |
work_keys_str_mv | AT carpenterwilliamt 22thenearfutureforschizophreniapsychosisresearch |