S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS

BACKGROUND: Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action (MOA) of current antipsychotics with dopamine D2 receptor antagonism. Phosphodiesterase 10A (PDE10A) inhibitors activate both direct and indirect pathway MSNs...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazunori, Harada, Akina, Suzuki, Hirobumi, Nakatani, Atsushi, Capuani, Clizia, Ugolini, Annarosa, Corsi, Mauro, Kaushal, Nidhi, Bobkov, Konstantin, Vekich, John, Doyle, Joseph, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887802/
http://dx.doi.org/10.1093/schbul/sby018.1010

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