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Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety

Low‐frequency oscillations with a dominant frequency at 0.1 Hz are one of the most influential intrinsic blood‐oxygen‐level‐dependent (BOLD) signals. This raises the question if vascular BOLD oscillations (originating from blood flow in the brain) and intrinsic slow neural activity fluctuations (neu...

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Autores principales: Pfurtscheller, Gert, Schwerdtfeger, Andreas, Seither‐Preisler, Annemarie, Brunner, Clemens, Aigner, Christoph Stefan, Calisto, João, Gens, João, Andrade, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887876/
https://www.ncbi.nlm.nih.gov/pubmed/29368814
http://dx.doi.org/10.1111/ejn.13845
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author Pfurtscheller, Gert
Schwerdtfeger, Andreas
Seither‐Preisler, Annemarie
Brunner, Clemens
Aigner, Christoph Stefan
Calisto, João
Gens, João
Andrade, Alexandre
author_facet Pfurtscheller, Gert
Schwerdtfeger, Andreas
Seither‐Preisler, Annemarie
Brunner, Clemens
Aigner, Christoph Stefan
Calisto, João
Gens, João
Andrade, Alexandre
author_sort Pfurtscheller, Gert
collection PubMed
description Low‐frequency oscillations with a dominant frequency at 0.1 Hz are one of the most influential intrinsic blood‐oxygen‐level‐dependent (BOLD) signals. This raises the question if vascular BOLD oscillations (originating from blood flow in the brain) and intrinsic slow neural activity fluctuations (neural BOLD oscillations) can be differentiated. In this study, we report on two different approaches: first, on computing the phase‐locking value in the frequency band 0.07–0.13 Hz between heart beat‐to‐beat interval (RRI) and BOLD oscillations and second, between multiple BOLD oscillations (functional connectivity) in four resting states in 23 scanner‐naïve, anxious healthy subjects. The first method revealed that vascular 0.1‐Hz BOLD oscillations preceded those in RRI signals by 1.7 ± 0.6 s and neural BOLD oscillations lagged RRI oscillations by 0.8 ± 0.5 s. Together, vascular BOLD oscillations preceded neural BOLD oscillations by ~90° or ~2.5 s. To verify this discrimination, connectivity patterns of neural and vascular 0.1‐Hz BOLD oscillations were compared in 26 regions involved in processing of emotions. Neural BOLD oscillations revealed significant phase‐coupling between amygdala and medial frontal cortex, while vascular BOLD oscillations showed highly significant phase‐coupling between amygdala and multiple regions in the supply areas of the anterior and medial cerebral arteries. This suggests that not only slow neural and vascular BOLD oscillations can be dissociated but also that two strategies may exist to optimize regulation of anxiety, that is increased functional connectivity between amygdala and medial frontal cortex, and increased cerebral blood flow in amygdala and related structures.
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spelling pubmed-58878762018-04-12 Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety Pfurtscheller, Gert Schwerdtfeger, Andreas Seither‐Preisler, Annemarie Brunner, Clemens Aigner, Christoph Stefan Calisto, João Gens, João Andrade, Alexandre Eur J Neurosci Neurosystems Low‐frequency oscillations with a dominant frequency at 0.1 Hz are one of the most influential intrinsic blood‐oxygen‐level‐dependent (BOLD) signals. This raises the question if vascular BOLD oscillations (originating from blood flow in the brain) and intrinsic slow neural activity fluctuations (neural BOLD oscillations) can be differentiated. In this study, we report on two different approaches: first, on computing the phase‐locking value in the frequency band 0.07–0.13 Hz between heart beat‐to‐beat interval (RRI) and BOLD oscillations and second, between multiple BOLD oscillations (functional connectivity) in four resting states in 23 scanner‐naïve, anxious healthy subjects. The first method revealed that vascular 0.1‐Hz BOLD oscillations preceded those in RRI signals by 1.7 ± 0.6 s and neural BOLD oscillations lagged RRI oscillations by 0.8 ± 0.5 s. Together, vascular BOLD oscillations preceded neural BOLD oscillations by ~90° or ~2.5 s. To verify this discrimination, connectivity patterns of neural and vascular 0.1‐Hz BOLD oscillations were compared in 26 regions involved in processing of emotions. Neural BOLD oscillations revealed significant phase‐coupling between amygdala and medial frontal cortex, while vascular BOLD oscillations showed highly significant phase‐coupling between amygdala and multiple regions in the supply areas of the anterior and medial cerebral arteries. This suggests that not only slow neural and vascular BOLD oscillations can be dissociated but also that two strategies may exist to optimize regulation of anxiety, that is increased functional connectivity between amygdala and medial frontal cortex, and increased cerebral blood flow in amygdala and related structures. John Wiley and Sons Inc. 2018-02-08 2018-03 /pmc/articles/PMC5887876/ /pubmed/29368814 http://dx.doi.org/10.1111/ejn.13845 Text en © 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neurosystems
Pfurtscheller, Gert
Schwerdtfeger, Andreas
Seither‐Preisler, Annemarie
Brunner, Clemens
Aigner, Christoph Stefan
Calisto, João
Gens, João
Andrade, Alexandre
Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title_full Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title_fullStr Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title_full_unstemmed Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title_short Synchronization of intrinsic 0.1‐Hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
title_sort synchronization of intrinsic 0.1‐hz blood‐oxygen‐level‐dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety
topic Neurosystems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887876/
https://www.ncbi.nlm.nih.gov/pubmed/29368814
http://dx.doi.org/10.1111/ejn.13845
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