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Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections

Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. Consecutive patients <13 years old with acute febrile illness during a 2‐year period were tested. HAdV strains were isolate...

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Autores principales: Nakamura, Haruna, Fujisawa, Takao, Suga, Shigeru, Taniguchi, Kiyosu, Nagao, Mizuho, Ito, Masahiro, Ochiai, Hitoshi, Konagaya, Masami, Hanaoka, Nozomu, Fujimoto, Tsuguto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887893/
https://www.ncbi.nlm.nih.gov/pubmed/29350418
http://dx.doi.org/10.1002/jmv.25032
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author Nakamura, Haruna
Fujisawa, Takao
Suga, Shigeru
Taniguchi, Kiyosu
Nagao, Mizuho
Ito, Masahiro
Ochiai, Hitoshi
Konagaya, Masami
Hanaoka, Nozomu
Fujimoto, Tsuguto
author_facet Nakamura, Haruna
Fujisawa, Takao
Suga, Shigeru
Taniguchi, Kiyosu
Nagao, Mizuho
Ito, Masahiro
Ochiai, Hitoshi
Konagaya, Masami
Hanaoka, Nozomu
Fujimoto, Tsuguto
author_sort Nakamura, Haruna
collection PubMed
description Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. Consecutive patients <13 years old with acute febrile illness during a 2‐year period were tested. HAdV strains were isolated from nasopharyngeal swabs, and molecular identification was performed by hexon, fiber, and species‐specific PCR methods. Blood inflammatory markers, including the white blood cell (WBC) count, CRP, and 29 cytokines, were measured. A total of 187 patients were enrolled, and HAdV types were identified from 175 patients (93.5%). Species C (types 2, 1, 5, and 6, in order of frequency) was most common at 37.1%, followed by B (type 3) at 30.9% and E (type 4) at 26.9%. Species C was detected predominantly in 1‐year‐old, whereas B and E were in older ages. Species C and B had seasonal circulation patterns, but E was found in only one season during the 2‐year study period. The WBC count was highest in patients with species C. Eleven of the 29 tested serum cytokines were detected. Seven kinds, including G‐CSF, IL‐6, and TNF‐α, were elevated in species C infections, whereas IL‐10 was lowest in species C. Species differences in inflammatory responses, especially regarding serum cytokines were described in common pediatric HAdV infections. Species C causes the strongest inflammatory responses in young children.
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spelling pubmed-58878932018-04-12 Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections Nakamura, Haruna Fujisawa, Takao Suga, Shigeru Taniguchi, Kiyosu Nagao, Mizuho Ito, Masahiro Ochiai, Hitoshi Konagaya, Masami Hanaoka, Nozomu Fujimoto, Tsuguto J Med Virol Research Articles Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. Consecutive patients <13 years old with acute febrile illness during a 2‐year period were tested. HAdV strains were isolated from nasopharyngeal swabs, and molecular identification was performed by hexon, fiber, and species‐specific PCR methods. Blood inflammatory markers, including the white blood cell (WBC) count, CRP, and 29 cytokines, were measured. A total of 187 patients were enrolled, and HAdV types were identified from 175 patients (93.5%). Species C (types 2, 1, 5, and 6, in order of frequency) was most common at 37.1%, followed by B (type 3) at 30.9% and E (type 4) at 26.9%. Species C was detected predominantly in 1‐year‐old, whereas B and E were in older ages. Species C and B had seasonal circulation patterns, but E was found in only one season during the 2‐year study period. The WBC count was highest in patients with species C. Eleven of the 29 tested serum cytokines were detected. Seven kinds, including G‐CSF, IL‐6, and TNF‐α, were elevated in species C infections, whereas IL‐10 was lowest in species C. Species differences in inflammatory responses, especially regarding serum cytokines were described in common pediatric HAdV infections. Species C causes the strongest inflammatory responses in young children. John Wiley and Sons Inc. 2018-02-07 2018-05 /pmc/articles/PMC5887893/ /pubmed/29350418 http://dx.doi.org/10.1002/jmv.25032 Text en © 2018 The Authors. Journal of Medical Virology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Nakamura, Haruna
Fujisawa, Takao
Suga, Shigeru
Taniguchi, Kiyosu
Nagao, Mizuho
Ito, Masahiro
Ochiai, Hitoshi
Konagaya, Masami
Hanaoka, Nozomu
Fujimoto, Tsuguto
Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title_full Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title_fullStr Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title_full_unstemmed Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title_short Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
title_sort species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887893/
https://www.ncbi.nlm.nih.gov/pubmed/29350418
http://dx.doi.org/10.1002/jmv.25032
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