Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate ca...

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Detalles Bibliográficos
Autores principales: Yan, Yuqian, An, Jian, Yang, Yinhui, Wu, Di, Bai, Yang, Cao, William, Ma, Linlin, Chen, Junhui, Yu, Zhendong, He, Yundong, Jin, Xin, Pan, Yunqian, Ma, Tao, Wang, Shangqian, Hou, Xiaonan, Weroha, Saravut John, Karnes, R Jeffrey, Zhang, Jun, Westendorf, Jennifer J, Wang, Liguo, Chen, Yu, Xu, Wanhai, Zhu, Runzhi, Wang, Dejie, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887910/
https://www.ncbi.nlm.nih.gov/pubmed/29523594
http://dx.doi.org/10.15252/emmm.201708478

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