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Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore

BACKGROUND: The prevalence of symptomatic knee osteoarthritis (KOA) in Singapore is unknown. We aimed to: (i) validate questionnaires to screen for symptomatic KOA; and (ii) estimate the prevalence of symptomatic KOA in Singapore using the validated algorithms. METHODS: Subjects aged ≥50 years were...

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Autores principales: Leung, Ying‐Ying, Ma, Stefan, Noviani, Maria, Wong, Steven B.‐S., Lee, Chee Min, Soh, Irene A.‐L., Thumboo, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887938/
https://www.ncbi.nlm.nih.gov/pubmed/29271108
http://dx.doi.org/10.1111/1756-185X.13252
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author Leung, Ying‐Ying
Ma, Stefan
Noviani, Maria
Wong, Steven B.‐S.
Lee, Chee Min
Soh, Irene A.‐L.
Thumboo, Julian
author_facet Leung, Ying‐Ying
Ma, Stefan
Noviani, Maria
Wong, Steven B.‐S.
Lee, Chee Min
Soh, Irene A.‐L.
Thumboo, Julian
author_sort Leung, Ying‐Ying
collection PubMed
description BACKGROUND: The prevalence of symptomatic knee osteoarthritis (KOA) in Singapore is unknown. We aimed to: (i) validate questionnaires to screen for symptomatic KOA; and (ii) estimate the prevalence of symptomatic KOA in Singapore using the validated algorithms. METHODS: Subjects aged ≥50 years were evaluated for symptomatic KOA based on American College of Rheumatology clinical and radiographic criteria in a rheumatology clinic, and completed three sets of adapted screening questionnaires. The better performing screening questionnaire with adequate sensitivity and specificity was adminitered to a nationally representative sample of survey subjects (n = 3364) to estimate the weighted prevalence of symptomatic KOA in Singapore. RESULTS: Out of 146 subjects evaluated in the clinic, 45 had symptomatic KOA. A screening algorithm which consisted of three KOA symptoms or one symptom plus physician‐diagnosed KOA produced high specificity (0.95, 95% confidence intervals [CI]: 0.88–0.98) but low sensivity (0.44, 95% CI: 0.30–0.60). Replacing the term ‘KOA’ with ‘physician‐diagnosed ageing‐related knee problem’ improved the sensivity (0.62, 95% CI: 0.47–0.76) without significantly compromising the specificity (0.87, 95% CI: 0.79–0.93). The prevalence of symptomatic KOA weighted to the Singapore population distribution were 4.7% and 11%, using the most conservative and more liberal algorithms, respectively. There was a sharp rise in prevalence after age of 40. The weighted prevalence of KOA was higher in women and among Indian and Malay than Chinese. CONCLUSION: Our study adapted and validated questionnaires to the local context to screen for symptomatic KOA. We estimated the prevalence of symptomatic KOA in Singapore utilizing the better‐performing algorithms.
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spelling pubmed-58879382018-04-12 Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore Leung, Ying‐Ying Ma, Stefan Noviani, Maria Wong, Steven B.‐S. Lee, Chee Min Soh, Irene A.‐L. Thumboo, Julian Int J Rheum Dis Original Articles BACKGROUND: The prevalence of symptomatic knee osteoarthritis (KOA) in Singapore is unknown. We aimed to: (i) validate questionnaires to screen for symptomatic KOA; and (ii) estimate the prevalence of symptomatic KOA in Singapore using the validated algorithms. METHODS: Subjects aged ≥50 years were evaluated for symptomatic KOA based on American College of Rheumatology clinical and radiographic criteria in a rheumatology clinic, and completed three sets of adapted screening questionnaires. The better performing screening questionnaire with adequate sensitivity and specificity was adminitered to a nationally representative sample of survey subjects (n = 3364) to estimate the weighted prevalence of symptomatic KOA in Singapore. RESULTS: Out of 146 subjects evaluated in the clinic, 45 had symptomatic KOA. A screening algorithm which consisted of three KOA symptoms or one symptom plus physician‐diagnosed KOA produced high specificity (0.95, 95% confidence intervals [CI]: 0.88–0.98) but low sensivity (0.44, 95% CI: 0.30–0.60). Replacing the term ‘KOA’ with ‘physician‐diagnosed ageing‐related knee problem’ improved the sensivity (0.62, 95% CI: 0.47–0.76) without significantly compromising the specificity (0.87, 95% CI: 0.79–0.93). The prevalence of symptomatic KOA weighted to the Singapore population distribution were 4.7% and 11%, using the most conservative and more liberal algorithms, respectively. There was a sharp rise in prevalence after age of 40. The weighted prevalence of KOA was higher in women and among Indian and Malay than Chinese. CONCLUSION: Our study adapted and validated questionnaires to the local context to screen for symptomatic KOA. We estimated the prevalence of symptomatic KOA in Singapore utilizing the better‐performing algorithms. John Wiley and Sons Inc. 2017-12-21 2018-03 /pmc/articles/PMC5887938/ /pubmed/29271108 http://dx.doi.org/10.1111/1756-185X.13252 Text en © 2017 The Authors International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Leung, Ying‐Ying
Ma, Stefan
Noviani, Maria
Wong, Steven B.‐S.
Lee, Chee Min
Soh, Irene A.‐L.
Thumboo, Julian
Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title_full Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title_fullStr Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title_full_unstemmed Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title_short Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore
title_sort validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of singapore
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887938/
https://www.ncbi.nlm.nih.gov/pubmed/29271108
http://dx.doi.org/10.1111/1756-185X.13252
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