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F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS

BACKGROUND: Social cognitive deficits are considered hallmark features of schizophrenia spectrum disorders. Consistent patterns of relationships have been established between theory of mind impairment and severity of negative symptoms. Some studies have suggested that patients, specifically those wi...

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Autores principales: Hajdúk, Michal, Pavelková, Lucia, Ohrablo, Peter, Petrušová, Veronika, Heretik, Anton, Forgáčová, Ľubica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888244/
http://dx.doi.org/10.1093/schbul/sby017.610
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author Hajdúk, Michal
Pavelková, Lucia
Ohrablo, Peter
Petrušová, Veronika
Heretik, Anton
Forgáčová, Ľubica
author_facet Hajdúk, Michal
Pavelková, Lucia
Ohrablo, Peter
Petrušová, Veronika
Heretik, Anton
Forgáčová, Ľubica
author_sort Hajdúk, Michal
collection PubMed
description BACKGROUND: Social cognitive deficits are considered hallmark features of schizophrenia spectrum disorders. Consistent patterns of relationships have been established between theory of mind impairment and severity of negative symptoms. Some studies have suggested that patients, specifically those with persecutory delusion, can over attribute intentions. Difficulties in theory of mind in patients with schizophrenia can vary between hypo and hyper – mentalization depending on the level of symptoms. The aim of the study was to test model which proposed hypo -mentalization vs. hyper - mentalization deficit in patients with schizophrenia spectrum disorders with persecutory delusions. METHODS: 40 patients diagnosed with schizophrenia spectrum disorder, 19 patients with anxiety, affective and personality disorders without persecutory delusions, and 28 healthy controls were enrolled in the study. Diagnoses were established according to ICD-10 criteria. Animation Task was used for theory of mind assessment. Task consists of 12 videos (moving triangles) with three types of stimuli (random, goal-directed and theory of mind – condition). Stimuli were presented in fixed, random order before symptom assessment. Participants were asked to describe content of videos, and the degree of intentionality and appropriateness was evaluated by two raters according to task`s manual. Mutual rating of raters was used in the present analysis. Brief Psychiatric Rating Scale was used for assessment of symptoms severity. RESULTS: A repeated measures ANOVA with stimuli type as within-factor and group as between-factor revealed significant effect of Stimuli type (F= 171.585, p < .001), and interaction of factors (F = 5.401, p = .001) on rating of intentionality. Group effect was not significant (F= .836, p = .437). Patients with schizophrenia had significantly lower ratings of intentionality in theory of mind condition, specifically. A second repeated measures ANOVA analyzed differences in levels of appropriateness. Results revealed significant effect of stimuli type (F= 12.698, p < .001), group (F= 6.966, p = .002) and interaction of factors (F = 3.211, p = .020). Responses of patients with schizophrenia were less appropriate than controls in goal-directed and theory of mind condition compared to the random condition. Severity of negative symptoms was associate with lower level of intentionality in random condition. Hostility and suspiciousness were associated with higher level of intentionality in goal directed (rs=.330, p=.037) and theory of mind conditions (rs=.348, p=.028). Severity of suspiciousness was moderately to strongly associated with appropriateness of descriptions in all conditions (rs from -.423 to -.517). DISCUSSION: Results of study highlighted importance of distinguishing between hyper- and hypo-mentalization in patients with schizophrenia as specific impairments were associated with positive and negative symptoms, respectively. Over attribution of intentions to random movement was moderately associated with paranoid symptoms. Patients provided less appropriate descriptions which was associated with higher level of suspiciousness. Implications for development, maintenance treatment of persecutory delusions will be discussed. Research was supported by Psychiatric Society of Slovak Medical Agency – grant no: 02/2015
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spelling pubmed-58882442018-04-11 F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS Hajdúk, Michal Pavelková, Lucia Ohrablo, Peter Petrušová, Veronika Heretik, Anton Forgáčová, Ľubica Schizophr Bull Abstracts BACKGROUND: Social cognitive deficits are considered hallmark features of schizophrenia spectrum disorders. Consistent patterns of relationships have been established between theory of mind impairment and severity of negative symptoms. Some studies have suggested that patients, specifically those with persecutory delusion, can over attribute intentions. Difficulties in theory of mind in patients with schizophrenia can vary between hypo and hyper – mentalization depending on the level of symptoms. The aim of the study was to test model which proposed hypo -mentalization vs. hyper - mentalization deficit in patients with schizophrenia spectrum disorders with persecutory delusions. METHODS: 40 patients diagnosed with schizophrenia spectrum disorder, 19 patients with anxiety, affective and personality disorders without persecutory delusions, and 28 healthy controls were enrolled in the study. Diagnoses were established according to ICD-10 criteria. Animation Task was used for theory of mind assessment. Task consists of 12 videos (moving triangles) with three types of stimuli (random, goal-directed and theory of mind – condition). Stimuli were presented in fixed, random order before symptom assessment. Participants were asked to describe content of videos, and the degree of intentionality and appropriateness was evaluated by two raters according to task`s manual. Mutual rating of raters was used in the present analysis. Brief Psychiatric Rating Scale was used for assessment of symptoms severity. RESULTS: A repeated measures ANOVA with stimuli type as within-factor and group as between-factor revealed significant effect of Stimuli type (F= 171.585, p < .001), and interaction of factors (F = 5.401, p = .001) on rating of intentionality. Group effect was not significant (F= .836, p = .437). Patients with schizophrenia had significantly lower ratings of intentionality in theory of mind condition, specifically. A second repeated measures ANOVA analyzed differences in levels of appropriateness. Results revealed significant effect of stimuli type (F= 12.698, p < .001), group (F= 6.966, p = .002) and interaction of factors (F = 3.211, p = .020). Responses of patients with schizophrenia were less appropriate than controls in goal-directed and theory of mind condition compared to the random condition. Severity of negative symptoms was associate with lower level of intentionality in random condition. Hostility and suspiciousness were associated with higher level of intentionality in goal directed (rs=.330, p=.037) and theory of mind conditions (rs=.348, p=.028). Severity of suspiciousness was moderately to strongly associated with appropriateness of descriptions in all conditions (rs from -.423 to -.517). DISCUSSION: Results of study highlighted importance of distinguishing between hyper- and hypo-mentalization in patients with schizophrenia as specific impairments were associated with positive and negative symptoms, respectively. Over attribution of intentions to random movement was moderately associated with paranoid symptoms. Patients provided less appropriate descriptions which was associated with higher level of suspiciousness. Implications for development, maintenance treatment of persecutory delusions will be discussed. Research was supported by Psychiatric Society of Slovak Medical Agency – grant no: 02/2015 Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5888244/ http://dx.doi.org/10.1093/schbul/sby017.610 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Hajdúk, Michal
Pavelková, Lucia
Ohrablo, Peter
Petrušová, Veronika
Heretik, Anton
Forgáčová, Ľubica
F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title_full F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title_fullStr F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title_full_unstemmed F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title_short F79. ATTRIBUTION OF INTENTIONS IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS WITH PERSECUTORY DELUSIONS
title_sort f79. attribution of intentions in patients with schizophrenia spectrum disorders with persecutory delusions
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888244/
http://dx.doi.org/10.1093/schbul/sby017.610
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