S221. QUANTITATIVE SYSTEMS PHARMACOLOGY AS AN ALTERNATIVE TO CHLORPROMAZINE EQUIVALENTS: PREDICTIVE VALIDATION FROM A CRIS DATABASE EXPERIMENT

BACKGROUND: Polypharmacy is common in real clinical practice and in pharma-sponsored clinical trials. Chlorpromazine equivalents do not take into account pharmacodynamic interactions of drug combinations. If there is a sufficiently deep calibration set available, bio-informatics approaches can build...

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Detalles Bibliográficos
Autores principales: Geerts, Hugo, Spiros, Athan, Kadra, Giouliana, Stewart, Robert, Hayes, Richard, Shetty, Hitesh, Iqbal, Ehtesham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888259/
http://dx.doi.org/10.1093/schbul/sby018.1008

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