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18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE

BACKGROUND: Neuropsychiatric disorders alter the structure and function of neural circuits and distributed neural networks, which leads to profound behavioral disability such as working memory impairment. Non-invasive neuroimaging tools have matured to reliably detect neural systems-level disturbanc...

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Autor principal: Anticevic, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888342/
http://dx.doi.org/10.1093/schbul/sby014.073
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author Anticevic, Alan
author_facet Anticevic, Alan
author_sort Anticevic, Alan
collection PubMed
description BACKGROUND: Neuropsychiatric disorders alter the structure and function of neural circuits and distributed neural networks, which leads to profound behavioral disability such as working memory impairment. Non-invasive neuroimaging tools have matured to reliably detect neural systems-level disturbances in neuropsychiatric disorders. However, mechanistic mapping from neural circuit pathology to abnormal behavior remains out of reach for most psychiatric conditions. We focus on the emerging field of ‘computational psychiatry’ to close these gaps from the perspective of E/I imbalance in schizophrenia with an emphasis on understanding large-Scale network dysconnectivity in schizophrenia. METHODS: First, we apply computational microcircuit models to understand cognitive and neural system-level disturbances in schizophrenia as a function of altered E/I balance. In turn, the focus is placed on pharmacological neuroimaging as a powerful causal tool to probe neural circuit perturbations. Specific recent neuroimaging studies are discussed that use the NMDA receptor antagonist, ketamine, to probe glutamate synaptic dysfunction associated with schizophrenia. We leverage resting-state neuroimaging advances to inform biomarker development for network alterations in schizophrenia given its ease of data collection and lack of task-based confounds. RESULTS: Pharmacological and clinical results implicate alterations in cortico-striato-thalamic circuits, which might constitute a final common pathway of neural system disturbances in schizophrenia. Results indicate that this functional marker appears in at-risk states, chronic patients, and following pharmacological manipulations following ketamine. Computational simulations implicate altered E/I balance in cortical microcircuits as a parsimonious upstream mechanism. DISCUSSION: The combined use of biophysical computational modeling, extended to large-scale neural system simulations, has proven particularly powerful to draw inferences about neural circuit alterations that may be ‘driving’ the resting-state dysconnectivity and cognitive deficits in schizophrenia. In summary, present data illustrates a framework for linking experimental studies in humans with computational models and pharmacological probes will advance to effort to bridge cellular, systems, and clinical neuroscience approaches to psychiatric disorders.
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spelling pubmed-58883422018-04-11 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE Anticevic, Alan Schizophr Bull Abstracts BACKGROUND: Neuropsychiatric disorders alter the structure and function of neural circuits and distributed neural networks, which leads to profound behavioral disability such as working memory impairment. Non-invasive neuroimaging tools have matured to reliably detect neural systems-level disturbances in neuropsychiatric disorders. However, mechanistic mapping from neural circuit pathology to abnormal behavior remains out of reach for most psychiatric conditions. We focus on the emerging field of ‘computational psychiatry’ to close these gaps from the perspective of E/I imbalance in schizophrenia with an emphasis on understanding large-Scale network dysconnectivity in schizophrenia. METHODS: First, we apply computational microcircuit models to understand cognitive and neural system-level disturbances in schizophrenia as a function of altered E/I balance. In turn, the focus is placed on pharmacological neuroimaging as a powerful causal tool to probe neural circuit perturbations. Specific recent neuroimaging studies are discussed that use the NMDA receptor antagonist, ketamine, to probe glutamate synaptic dysfunction associated with schizophrenia. We leverage resting-state neuroimaging advances to inform biomarker development for network alterations in schizophrenia given its ease of data collection and lack of task-based confounds. RESULTS: Pharmacological and clinical results implicate alterations in cortico-striato-thalamic circuits, which might constitute a final common pathway of neural system disturbances in schizophrenia. Results indicate that this functional marker appears in at-risk states, chronic patients, and following pharmacological manipulations following ketamine. Computational simulations implicate altered E/I balance in cortical microcircuits as a parsimonious upstream mechanism. DISCUSSION: The combined use of biophysical computational modeling, extended to large-scale neural system simulations, has proven particularly powerful to draw inferences about neural circuit alterations that may be ‘driving’ the resting-state dysconnectivity and cognitive deficits in schizophrenia. In summary, present data illustrates a framework for linking experimental studies in humans with computational models and pharmacological probes will advance to effort to bridge cellular, systems, and clinical neuroscience approaches to psychiatric disorders. Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5888342/ http://dx.doi.org/10.1093/schbul/sby014.073 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Anticevic, Alan
18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title_full 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title_fullStr 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title_full_unstemmed 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title_short 18.4 CHARACTERIZING LARGE-SCALE NETWORK DYSCONNECTIVITY IN SCHIZOPHRENIA: MODELING ALTERED E/I BALANCE
title_sort 18.4 characterizing large-scale network dysconnectivity in schizophrenia: modeling altered e/i balance
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888342/
http://dx.doi.org/10.1093/schbul/sby014.073
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