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F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY
BACKGROUND: Short telomere length is a biomarker of cell oxidation and aging. Patients with first-episode psychosis (FEP) have been reported to have shorter telomeres than healthy controls (HC), suggesting that there is a premature and accelerated cellular aging in FEP. However, there are not data o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888372/ http://dx.doi.org/10.1093/schbul/sby017.550 |
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author | Fraguas, David Recio, Sandra Diaz-Caneja, Covadonga M Blasco, Maria A Moisés, Ana Carolina Arango, Celso |
author_facet | Fraguas, David Recio, Sandra Diaz-Caneja, Covadonga M Blasco, Maria A Moisés, Ana Carolina Arango, Celso |
author_sort | Fraguas, David |
collection | PubMed |
description | BACKGROUND: Short telomere length is a biomarker of cell oxidation and aging. Patients with first-episode psychosis (FEP) have been reported to have shorter telomeres than healthy controls (HC), suggesting that there is a premature and accelerated cellular aging in FEP. However, there are not data on longitudinal changes of telomere length in people with FEP relative to HC. We present preliminary results on 1-year longitudinal changes in peripheral blood mononuclear cells (PBMCs) telomere length and the proportion of PBMCs with short telomeres in young people with FEP and HC. METHODS: 16 young patients with FEP (43.8% female, mean age 17.9 years) and 21 young HC (61.9% female, mean age 16.6 years) were enrolled in the study. PBMCs telomere length and the proportion of PBMCs with short telomeres (i.e. <3kb) were determined using high-throughput quantitative fluorescence in situ hybridization (HT Q-FISH) at baseline (16 patients with FEP and 21 HC) and 12-month follow-up (4 patients with FEP and 4 HC). RESULTS: At baseline, we did not find significant differences in telomere length nor in proportion of PBMCs with short telomeres between FEP patients and HC. During the one-year follow-up, we found a significantly greater loss of telomere length (p=0.019; explained variance=69.7%) and a non-significantly trend for greater increase in the proportion of PBMCs with short telomeres (p=0.097; explained variance=45.5%) in patients with FEP than in HC. DISCUSSION: Telomere length changes during the first years of the illness can represent an early marker of accelerated cellular aging in patients with first-episode psychosis. |
format | Online Article Text |
id | pubmed-5888372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58883722018-04-11 F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY Fraguas, David Recio, Sandra Diaz-Caneja, Covadonga M Blasco, Maria A Moisés, Ana Carolina Arango, Celso Schizophr Bull Abstracts BACKGROUND: Short telomere length is a biomarker of cell oxidation and aging. Patients with first-episode psychosis (FEP) have been reported to have shorter telomeres than healthy controls (HC), suggesting that there is a premature and accelerated cellular aging in FEP. However, there are not data on longitudinal changes of telomere length in people with FEP relative to HC. We present preliminary results on 1-year longitudinal changes in peripheral blood mononuclear cells (PBMCs) telomere length and the proportion of PBMCs with short telomeres in young people with FEP and HC. METHODS: 16 young patients with FEP (43.8% female, mean age 17.9 years) and 21 young HC (61.9% female, mean age 16.6 years) were enrolled in the study. PBMCs telomere length and the proportion of PBMCs with short telomeres (i.e. <3kb) were determined using high-throughput quantitative fluorescence in situ hybridization (HT Q-FISH) at baseline (16 patients with FEP and 21 HC) and 12-month follow-up (4 patients with FEP and 4 HC). RESULTS: At baseline, we did not find significant differences in telomere length nor in proportion of PBMCs with short telomeres between FEP patients and HC. During the one-year follow-up, we found a significantly greater loss of telomere length (p=0.019; explained variance=69.7%) and a non-significantly trend for greater increase in the proportion of PBMCs with short telomeres (p=0.097; explained variance=45.5%) in patients with FEP than in HC. DISCUSSION: Telomere length changes during the first years of the illness can represent an early marker of accelerated cellular aging in patients with first-episode psychosis. Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5888372/ http://dx.doi.org/10.1093/schbul/sby017.550 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Fraguas, David Recio, Sandra Diaz-Caneja, Covadonga M Blasco, Maria A Moisés, Ana Carolina Arango, Celso F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title | F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title_full | F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title_fullStr | F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title_full_unstemmed | F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title_short | F19. TELOMERE SHORTENING IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY |
title_sort | f19. telomere shortening in young people with first episode psychosis: a 12-month follow-up study |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888372/ http://dx.doi.org/10.1093/schbul/sby017.550 |
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