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S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA

BACKGROUND: Up to 25% of schizophrenia patients continue to experience distressing auditory hallucinations despite best efforts at treatment with antipsychotic drugs. Transcranial direct current stimulation (tDCS) has been suggested to rapidly attenuate such persistent hallucinations. METHODS: We tr...

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Autores principales: Goyal, Parth, Kataria, Lakhan, Andrade, Chittaranjan, Desai, Priyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888469/
http://dx.doi.org/10.1093/schbul/sby018.992
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author Goyal, Parth
Kataria, Lakhan
Andrade, Chittaranjan
Desai, Priyal
author_facet Goyal, Parth
Kataria, Lakhan
Andrade, Chittaranjan
Desai, Priyal
author_sort Goyal, Parth
collection PubMed
description BACKGROUND: Up to 25% of schizophrenia patients continue to experience distressing auditory hallucinations despite best efforts at treatment with antipsychotic drugs. Transcranial direct current stimulation (tDCS) has been suggested to rapidly attenuate such persistent hallucinations. METHODS: We treated 23 schizophrenia patients with persistent, antipsychotic-refractory auditory hallucinations using tDCS in a single-group, open-label design. tDCS was administered at 2 mA current intensity for 20 min, twice-daily and 4 h apart, across 5 consecutive days; the anode was placed over the the left dorsolateral prefrontal cortex and the cathode over the left temporoparietal junction. Ongoing antipsychotic medications were continued unchanged. Patients were assessed using the Auditory Hallucinations Rating Scale (AHRS) at treatment endpoint and at 1- and 3-month follow up. Response was defined as 50% or greater attenuation in AHRS scores. RESULTS: All patients completed the study. tDCS resulted in substantial improvement. Mean (standard deviation) AHRS scores dropped from 29.0(8.3) at baseline to 4.4(5.6) at treatment endpoint; these values were 9.3(9.3) and 7.8(8.4) at 1- and 3-months follow up. The response rate was 91.3%, 69.6%, and 82.6% at the 3 posttreatment assessment points, respectively. Complete remission of hallucinations (AHRS=0) was observed in 61%, 44%, and 44% at the 3 posttreatment assessment points. tDCS was very well tolerated and adverse effects were minimal. DISCUSSION: tDCS is effective and well tolerated in schizophrenia patients with persistent, antipsychotic-refractory auditory hallucinations. In most patients, the benefits last for up to 3 months or longer.
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spelling pubmed-58884692018-04-11 S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA Goyal, Parth Kataria, Lakhan Andrade, Chittaranjan Desai, Priyal Schizophr Bull Abstracts BACKGROUND: Up to 25% of schizophrenia patients continue to experience distressing auditory hallucinations despite best efforts at treatment with antipsychotic drugs. Transcranial direct current stimulation (tDCS) has been suggested to rapidly attenuate such persistent hallucinations. METHODS: We treated 23 schizophrenia patients with persistent, antipsychotic-refractory auditory hallucinations using tDCS in a single-group, open-label design. tDCS was administered at 2 mA current intensity for 20 min, twice-daily and 4 h apart, across 5 consecutive days; the anode was placed over the the left dorsolateral prefrontal cortex and the cathode over the left temporoparietal junction. Ongoing antipsychotic medications were continued unchanged. Patients were assessed using the Auditory Hallucinations Rating Scale (AHRS) at treatment endpoint and at 1- and 3-month follow up. Response was defined as 50% or greater attenuation in AHRS scores. RESULTS: All patients completed the study. tDCS resulted in substantial improvement. Mean (standard deviation) AHRS scores dropped from 29.0(8.3) at baseline to 4.4(5.6) at treatment endpoint; these values were 9.3(9.3) and 7.8(8.4) at 1- and 3-months follow up. The response rate was 91.3%, 69.6%, and 82.6% at the 3 posttreatment assessment points, respectively. Complete remission of hallucinations (AHRS=0) was observed in 61%, 44%, and 44% at the 3 posttreatment assessment points. tDCS was very well tolerated and adverse effects were minimal. DISCUSSION: tDCS is effective and well tolerated in schizophrenia patients with persistent, antipsychotic-refractory auditory hallucinations. In most patients, the benefits last for up to 3 months or longer. Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5888469/ http://dx.doi.org/10.1093/schbul/sby018.992 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Goyal, Parth
Kataria, Lakhan
Andrade, Chittaranjan
Desai, Priyal
S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title_full S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title_fullStr S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title_full_unstemmed S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title_short S205. TRANSCRANIAL DIRECT CURRENT STIMULATION FOR SEVERE, PERSISTENT, TREATMENT-REFRACTORY AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA
title_sort s205. transcranial direct current stimulation for severe, persistent, treatment-refractory auditory hallucinations in schizophrenia
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888469/
http://dx.doi.org/10.1093/schbul/sby018.992
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