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3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS

Overall Abstract: Evidence is accumulating that core features of schizophrenia (SCH) may arise from a fundamental disturbance in the cellular balance of excitation and inhibition (E-I balance) within neural circuitry. In the symposium, we will provide a comprehensive overview of E-I balance alterati...

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Autor principal: Kegeles, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888476/
http://dx.doi.org/10.1093/schbul/sby014.002
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author Kegeles, Lawrence
author_facet Kegeles, Lawrence
author_sort Kegeles, Lawrence
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description Overall Abstract: Evidence is accumulating that core features of schizophrenia (SCH) may arise from a fundamental disturbance in the cellular balance of excitation and inhibition (E-I balance) within neural circuitry. In the symposium, we will provide a comprehensive overview of E-I balance alterations in SCH with evidence from preclinical models and in vivo measurements investigating potential neurobiological mechanisms underlying these dysfunctions as well as interventions that remedy these disturbances. Takao Hensch will summarize findings on critical period plasticity and its potential role in vulnerability to schizophrenia. He will present new preclinical data on the destabilizing consequences of enhanced gamma oscillations, which reversibly prolong juvenile forms of brain plasticity by redox imbalance. Jan-Harry Cabungcal will address the role of redox dysregulation and oxidative stress in the pathophysiology of schizophrenia. He will present recent data on the relationship of deficits of the perineuronal net and oxidative stress in the anterior cingulate cortex, and evidence that redox dysregulation can be targeted with antioxidants/redox regulators across animal models. Lawrence Kegeles will present simultaneous EEG and proton MRS measurements of glutamate and GABA during ketamine administration in healthy young adults. These data will be compared with the same modalities acquired in individuals at clinical high risk and patients with SCH, showing disturbed delta and gamma band power and altered E-I balance despite homeostatic rebalancing of glutamate and GABA. Peter Uhlhaas will summarize evidence from EEG/MEG data examining the potential role of neural oscillations in the pathophysiology of schizophrenia. He will show that alterations in gamma-band oscillations are present prior to the onset of schizophrenia in at-risk individuals and related to aberrant E-I balance parameters revealed by MRS-measured levels of GABA and glutamate. Developmental data on the maturation of neural oscillations suggests that the transition from adolescence to adulthood is a sensitive period for modifications in neuronal dynamics that could potentially explain the manifestation of psychosis during this period.
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spelling pubmed-58884762018-04-11 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS Kegeles, Lawrence Schizophr Bull Abstracts Overall Abstract: Evidence is accumulating that core features of schizophrenia (SCH) may arise from a fundamental disturbance in the cellular balance of excitation and inhibition (E-I balance) within neural circuitry. In the symposium, we will provide a comprehensive overview of E-I balance alterations in SCH with evidence from preclinical models and in vivo measurements investigating potential neurobiological mechanisms underlying these dysfunctions as well as interventions that remedy these disturbances. Takao Hensch will summarize findings on critical period plasticity and its potential role in vulnerability to schizophrenia. He will present new preclinical data on the destabilizing consequences of enhanced gamma oscillations, which reversibly prolong juvenile forms of brain plasticity by redox imbalance. Jan-Harry Cabungcal will address the role of redox dysregulation and oxidative stress in the pathophysiology of schizophrenia. He will present recent data on the relationship of deficits of the perineuronal net and oxidative stress in the anterior cingulate cortex, and evidence that redox dysregulation can be targeted with antioxidants/redox regulators across animal models. Lawrence Kegeles will present simultaneous EEG and proton MRS measurements of glutamate and GABA during ketamine administration in healthy young adults. These data will be compared with the same modalities acquired in individuals at clinical high risk and patients with SCH, showing disturbed delta and gamma band power and altered E-I balance despite homeostatic rebalancing of glutamate and GABA. Peter Uhlhaas will summarize evidence from EEG/MEG data examining the potential role of neural oscillations in the pathophysiology of schizophrenia. He will show that alterations in gamma-band oscillations are present prior to the onset of schizophrenia in at-risk individuals and related to aberrant E-I balance parameters revealed by MRS-measured levels of GABA and glutamate. Developmental data on the maturation of neural oscillations suggests that the transition from adolescence to adulthood is a sensitive period for modifications in neuronal dynamics that could potentially explain the manifestation of psychosis during this period. Oxford University Press 2018-04 2018-04-01 /pmc/articles/PMC5888476/ http://dx.doi.org/10.1093/schbul/sby014.002 Text en © Maryland Psychiatric Research Center 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Kegeles, Lawrence
3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title_full 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title_fullStr 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title_full_unstemmed 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title_short 3. EXCITATION-INHIBITION IMBALANCES IN SCHIZOPHRENIA: MECHANISMS AND INTERVENTIONS
title_sort 3. excitation-inhibition imbalances in schizophrenia: mechanisms and interventions
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888476/
http://dx.doi.org/10.1093/schbul/sby014.002
work_keys_str_mv AT kegeleslawrence 3excitationinhibitionimbalancesinschizophreniamechanismsandinterventions