Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases

BACKGROUND: Fusion of DNA methyltransferase domains to the nuclease-deficient clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has been used for epigenome editing, but the specificities of these dCas9 methyltransferases have not been fully investigated....

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Detalles Bibliográficos
Autores principales: Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Fløe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, Wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888497/
https://www.ncbi.nlm.nih.gov/pubmed/29635374
http://dx.doi.org/10.1093/gigascience/giy011

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