S43. A PROOF-OF-MECHANISM STUDY OF THE PDE10 INHIBITOR RG7203 IN PATIENTS WITH PROBING REWARD FUNCTIONS WITH IMAGING AND BEHAVIORAL APPROACHES

BACKGROUND: The enzyme phosphodiesterase 10A (PDE10A) is highly expressed in the striatum where it modulates both dopamine D2 and D1 dependent signaling. Its inhibition leads to a suppression of D2 mediated signaling –similar to effects of D2 antagonists - and an enhancement of D1 dependent signalin...

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Detalles Bibliográficos
Autores principales: Umbricht, Daniel, Dukart, Jürgen, Abt, Markus, Tamburri, Paul, Chatham, Chris, Frank, Michael, Collins, Anne, Walling, David, Mofsen, Rick, Gruener, Daniel, Gertsik, Lev, Sevigny, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888501/
http://dx.doi.org/10.1093/schbul/sby018.830

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