eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes

Increased activity of the mRNA helicase eIF4A drives cellular malignancy by reprogramming cellular translation, and eIF4A activity is the direct or indirect target of many emerging cancer therapeutics. The enriched presence of (GGC)(4) motifs, which have the potential to fold into two-layered G-quad...

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Detalles Bibliográficos
Autores principales: Waldron, Joseph A, Raza, Farheen, Le Quesne, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888628/
https://www.ncbi.nlm.nih.gov/pubmed/29471358
http://dx.doi.org/10.1093/nar/gky108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888628/
https://www.ncbi.nlm.nih.gov/pubmed/29471358
http://dx.doi.org/10.1093/nar/gky108

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