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eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes
Increased activity of the mRNA helicase eIF4A drives cellular malignancy by reprogramming cellular translation, and eIF4A activity is the direct or indirect target of many emerging cancer therapeutics. The enriched presence of (GGC)(4) motifs, which have the potential to fold into two-layered G-quad...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888628/ https://www.ncbi.nlm.nih.gov/pubmed/29471358 http://dx.doi.org/10.1093/nar/gky108 |