Replication stress induces accumulation of FANCD2 at central region of large fragile genes

During mild replication stress provoked by low dose aphidicolin (APH) treatment, the key Fanconi anemia protein FANCD2 accumulates on common fragile sites, observed as sister foci, and protects genome stability. To gain further insights into FANCD2 function and its regulatory mechanisms, we examined...

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Detalles Bibliográficos
Autores principales: Okamoto, Yusuke, Iwasaki, Watal M, Kugou, Kazuto, Takahashi, Kazuki K, Oda, Arisa, Sato, Koichi, Kobayashi, Wataru, Kawai, Hidehiko, Sakasai, Ryo, Takaori-Kondo, Akifumi, Yamamoto, Takashi, Kanemaki, Masato T, Taoka, Masato, Isobe, Toshiaki, Kurumizaka, Hitoshi, Innan, Hideki, Ohta, Kunihiro, Ishiai, Masamichi, Takata, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888676/
https://www.ncbi.nlm.nih.gov/pubmed/29394375
http://dx.doi.org/10.1093/nar/gky058

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