Cargando…
F234. TYPICAL AND ATYPICAL ANTIPSYCHOTICS’ D2R AFFINITY AND DOSES INFLUENCES POSTSYNAPTIC DENSITY BY MODULATING THE SPATIAL EXPRESSION OF HOMER1A A GENE HIGHLY IMPLICATED IN SYNAPTIC PLASTICITY AND PSYCHOSIS
BACKGROUND: Post-synaptic density (PSD) is an ultra-specialized structure of excitatory synapses composed by a large variety of molecules (scaffolding proteins, glutamate receptors, cytoskeleton proteins). PSD has been implicated in synaptic plasticity, memory formation and in the pathophysiology of...
Autores principales: | Camilla, Avagliano, Buonaguro, Elisabetta, Tomasetti, Carmine, Marmo, Federica, Vellucci, Licia, Iasevoli, Felice, de Bartolomeis, Andrea |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888784/ http://dx.doi.org/10.1093/schbul/sby017.765 |
Ejemplares similares
-
PM437. Spatial and temporal modulation of Homer1a gene expression at the post-synaptic density is related to D2R affinity and dose of antipsychotics: translational considerations for schizophrenia treatment strategies.
por: de Bartolomeis, Andrea, et al.
Publicado: (2016) -
S205. A TRANSLATIONAL HOMER 1A-BASED NETWORK APPROACH: IMAGING HOW HALOPERIDOL MODULATES GLUTAMATE SYSTEM FUNCTIONAL CONNECTIVITY
por: Vellucci, Licia, et al.
Publicado: (2020) -
The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted
por: Iasevoli, Felice, et al.
Publicado: (2020) -
The Glutamatergic Aspects of Schizophrenia Molecular Pathophysiology: Role of the Postsynaptic Density, and Implications for Treatment
por: Iasevoli, Felice, et al.
Publicado: (2014) -
Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia
por: de Bartolomeis, Andrea, et al.
Publicado: (2020)