Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer–promoter contacts

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Genomic binding of transcription factors, like the glucocorticoid receptor (GR), is linked to the regulation of genes. However, as we show here, GR binding is a poor predictor of GR-dependent gene regulation even when taking the 3D organization of the genome into account. To connect GR binding sites...

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Detalles Bibliográficos
Autores principales: Thormann, Verena, Rothkegel, Maika C, Schöpflin, Robert, Glaser, Laura V, Djuric, Petar, Li, Na, Chung, Ho-Ryun, Schwahn, Kevin, Vingron, Martin, Meijsing, Sebastiaan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888794/
https://www.ncbi.nlm.nih.gov/pubmed/29385519
http://dx.doi.org/10.1093/nar/gky051

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