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Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-β signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis

INTRODUCTION: Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) are often described as the initial pro-fibrotic mediators upregulated early in fibrosis models dependent on angiotensin II (Ang-II). In the present study, we explore the mechanistic link between TGF-β and C...

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Detalles Bibliográficos
Autores principales:	Wong, Chloe Kok Sum, Falkenham, Alec, Myers, Tanya, Légaré, Jean-Francois
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888824/ https://www.ncbi.nlm.nih.gov/pubmed/29575960 http://dx.doi.org/10.1177/1470320318759358

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