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[PIN(+)]ing down the mechanism of prion appearance

Prions are conformationally flexible proteins capable of adopting a native state and a spectrum of alternative states associated with a change in the function of the protein. These alternative states are prone to assemble into amyloid aggregates, which provide a structure for self-replication and tr...

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Detalles Bibliográficos
Autor principal: Serio, Tricia R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889010/
https://www.ncbi.nlm.nih.gov/pubmed/29718197
http://dx.doi.org/10.1093/femsyr/foy026