Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica

Autoantibodies to aquaporin-4 (AQP4) are pathogenic in neuromyelitis optica spectrum disorder (NMOSD). However, it is not known which B cells are the major contributors to circulating AQP4 antibodies nor which conditions promote their generation. Our experiments showed CD19(+)CD27(++)CD38(++) circul...

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Detalles Bibliográficos
Autores principales: Wilson, Robert, Makuch, Mateusz, Kienzler, Anne-Kathrin, Varley, James, Taylor, Jennifer, Woodhall, Mark, Palace, Jacqueline, Leite, M Isabel, Waters, Patrick, Irani, Sarosh R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889028/
https://www.ncbi.nlm.nih.gov/pubmed/29447335
http://dx.doi.org/10.1093/brain/awy010

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