Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma

BACKGROUND: A major limitation of circulating tumor DNA (ctDNA) for somatic mutation detection has been the low level of ctDNA found in a subset of cancer patients. We investigated whether using a combined isolation of exosomal RNA (exoRNA) and cell-free DNA (cfDNA) could improve blood-based liquid...

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Detalles Bibliográficos
Autores principales: Krug, A K, Enderle, D, Karlovich, C, Priewasser, T, Bentink, S, Spiel, A, Brinkmann, K, Emenegger, J, Grimm, D G, Castellanos-Rizaldos, E, Goldman, J W, Sequist, L V, Soria, J -C, Camidge, D R, Gadgeel, S M, Wakelee, H A, Raponi, M, Noerholm, M, Skog, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889041/
https://www.ncbi.nlm.nih.gov/pubmed/29216356
http://dx.doi.org/10.1093/annonc/mdx765

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