Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and screened for improved neutralization. Variants with the la...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwon, Young D., Chuang, Gwo-Yu, Zhang, Baoshan, Bailer, Robert T., Doria-Rose, Nicole A., Gindin, Tatyana S., Lin, Bob, Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Pegu, Amarendra, Schmidt, Stephen D., Asokan, Mangaiarkarasi, Chen, Xuejun, Choe, Misook, Georgiev, Ivelin S., Jin, Vivian, Pancera, Marie, Rawi, Reda, Wang, Keyun, Chaudhuri, Rajoshi, Kueltzo, Lisa A., Manceva, Slobodanka D., Todd, John-Paul, Scorpio, Diana G., Kim, Mikyung, Reinherz, Ellis L., Wagh, Kshitij, Korber, Bette M., Connors, Mark, Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889116/
https://www.ncbi.nlm.nih.gov/pubmed/29444432
http://dx.doi.org/10.1016/j.celrep.2018.01.023

Ejemplares similares

Ejemplares similares