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PIKfyve regulates melanosome biogenesis
PIKfyve, VAC14, and FIG4 form a complex that catalyzes the production of PI(3,5)P(2), a signaling lipid implicated in process ranging from lysosome maturation to neurodegeneration. While previous studies have identified VAC14 and FIG4 mutations that lead to both neurodegeneration and coat color defe...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889185/ https://www.ncbi.nlm.nih.gov/pubmed/29584722 http://dx.doi.org/10.1371/journal.pgen.1007290 |