S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity

Liver-related autoimmune toxicities triggered by agonistic anti-CD137 antibodies have greatly limited their use in clinical applications. Here, we found that anti-CD137 monoclonal antibody (mAb) treatment in mice induced the infiltration of a large number of S100A4(+) macrophages into the liver. Dep...

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Detalles Bibliográficos
Autores principales: Zhang, Jinhua, Song, Kun, Wang, Jun, Li, Yanan, Liu, Shuangqing, Dai, Chengliang, Chen, Lieping, Wang, Shengdian, Qin, Zhihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889198/
https://www.ncbi.nlm.nih.gov/pubmed/29632708
http://dx.doi.org/10.1080/2162402X.2017.1296996

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