Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

Neurofibromatosis type 2 (NF2) is a tumor-forming disease of the nervous system caused by deletion or by loss-of-function mutations in NF2, encoding the tumor suppressing protein neurofibromin 2 (also known as schwannomin or merlin). Neurofibromin 2 is a member of the ezrin, radixin, moesin (ERM) fa...

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Detalles Bibliográficos
Autores principales: Chinthalapudi, Krishna, Mandati, Vinay, Zheng, Jie, Sharff, Andrew J., Bricogne, Gerard, Griffin, Patrick R., Kissil, Joseph, Izard, Tina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889391/
https://www.ncbi.nlm.nih.gov/pubmed/29626191
http://dx.doi.org/10.1038/s41467-018-03648-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889391/
https://www.ncbi.nlm.nih.gov/pubmed/29626191
http://dx.doi.org/10.1038/s41467-018-03648-4

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