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Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
Neurofibromatosis type 2 (NF2) is a tumor-forming disease of the nervous system caused by deletion or by loss-of-function mutations in NF2, encoding the tumor suppressing protein neurofibromin 2 (also known as schwannomin or merlin). Neurofibromin 2 is a member of the ezrin, radixin, moesin (ERM) fa...
Autores principales: | Chinthalapudi, Krishna, Mandati, Vinay, Zheng, Jie, Sharff, Andrew J., Bricogne, Gerard, Griffin, Patrick R., Kissil, Joseph, Izard, Tina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889391/ https://www.ncbi.nlm.nih.gov/pubmed/29626191 http://dx.doi.org/10.1038/s41467-018-03648-4 |
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