Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Glucocorticoids (GCs) are potent repressors of NF-κB activity, making them a preferred choice for treatment of inflammation-driven conditions. Despite the widespread use of GCs in the clinic, current models are inadequate to explain the role of the glucocorticoid receptor (GR) within this critical s...

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Detalles Bibliográficos
Autores principales: Hudson, William H., Vera, Ian Mitchelle S. de, Nwachukwu, Jerome C., Weikum, Emily R., Herbst, Austin G., Yang, Qin, Bain, David L., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889392/
https://www.ncbi.nlm.nih.gov/pubmed/29626214
http://dx.doi.org/10.1038/s41467-018-03780-1

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