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Helicobacter pylori infection in subjects negative for high titer serum antibody

AIM: To investigate the clinicopathological features of the patients testing negative for high titer serum anti-Helicobacter pylori (H. pylori) antibody. METHODS: The antibody titers were measured using antigens derived from Japanese individuals. (13)C-urea breath test-positive individuals were defi...

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Detalles Bibliográficos
Autores principales: Toyoshima, Osamu, Nishizawa, Toshihiro, Arita, Masahide, Kataoka, Yosuke, Sakitani, Kosuke, Yoshida, Shuntaro, Yamashita, Hiroharu, Hata, Keisuke, Watanabe, Hidenobu, Suzuki, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889822/
https://www.ncbi.nlm.nih.gov/pubmed/29632423
http://dx.doi.org/10.3748/wjg.v24.i13.1419
Descripción
Sumario:AIM: To investigate the clinicopathological features of the patients testing negative for high titer serum anti-Helicobacter pylori (H. pylori) antibody. METHODS: The antibody titers were measured using antigens derived from Japanese individuals. (13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness. RESULTS: Of the 136 subjects enrolled, 23 (17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve (0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10(-20)) for predicting H. pylori infection with a cut-off value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies (89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate analysis. CONCLUSION: Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients.