Cargando…

The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study

BACKGROUND: The major aim of this study was evaluating the effect of atorvastatin treatment on thiobarbituric acid reactive substances (TBARS), ferric reducing the ability of plasma (FRAP), small dense low-density lipoprotein cholesterol (sdLDL) and lipid profile in coronary artery disease (CAD) pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahsavari, Gholamreza, Raoufi, Amir, Toolabi, Aram, Hosseninejadmir, Nahid, Ahmadvand, Hassan, Safariebrahimsarabie, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889919/
https://www.ncbi.nlm.nih.gov/pubmed/29643923
_version_ 1783312775296057344
author Shahsavari, Gholamreza
Raoufi, Amir
Toolabi, Aram
Hosseninejadmir, Nahid
Ahmadvand, Hassan
Safariebrahimsarabie, Mehdi
author_facet Shahsavari, Gholamreza
Raoufi, Amir
Toolabi, Aram
Hosseninejadmir, Nahid
Ahmadvand, Hassan
Safariebrahimsarabie, Mehdi
author_sort Shahsavari, Gholamreza
collection PubMed
description BACKGROUND: The major aim of this study was evaluating the effect of atorvastatin treatment on thiobarbituric acid reactive substances (TBARS), ferric reducing the ability of plasma (FRAP), small dense low-density lipoprotein cholesterol (sdLDL) and lipid profile in coronary artery disease (CAD) patients. METHODS: This study was carried out on 83 patients with angiographically proven coronary artery stenosis (52 men and 31 women) at Shahid Madani Hospital, Khorramabad, Iran, in 2015. The patients were divided into the 3 groups. 27 patients were classified statins consumption less than 6 days, 28 patients for 6 to 90 days, and 28 patients for more than 90 days. The level of sdLDL, lipid profile, TBARS and FRAP were assayed. RESULTS: FRAP levels of patients that received atorvastatin for more than 90 days (832 ± 101) were significantly elevated (P = 0.01) compared to the patients received atorvastatin less than 6 days (688 ± 75), whereas the levels of TBARS diminished significantly (P = 0.04). Also, the levels of total cholesterol (TC) and LDL-C were significantly decreased after 3 months of atorvastatin receiving (158 as compared to patients that consumed atorvastatin less than 6 days), (P = 0.02 and 0.03, respectively). The level of sdLDL was slightly increased with long-time consumption of atorvastatin (37 ± 14) in patients in comparison with patients that received atorvastatin less than 6 days (32 ± 15) (P = 0.06), but was not significant. CONCLUSION: The serum level of TBARS decreased and the serum level of FRAP increased in patients with long-time receiving atorvastatin. Therefore, atorvastatin contributes to the lowering oxidative stress in these patients.
format Online
Article
Text
id pubmed-5889919
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-58899192018-04-11 The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study Shahsavari, Gholamreza Raoufi, Amir Toolabi, Aram Hosseninejadmir, Nahid Ahmadvand, Hassan Safariebrahimsarabie, Mehdi ARYA Atheroscler Original Article BACKGROUND: The major aim of this study was evaluating the effect of atorvastatin treatment on thiobarbituric acid reactive substances (TBARS), ferric reducing the ability of plasma (FRAP), small dense low-density lipoprotein cholesterol (sdLDL) and lipid profile in coronary artery disease (CAD) patients. METHODS: This study was carried out on 83 patients with angiographically proven coronary artery stenosis (52 men and 31 women) at Shahid Madani Hospital, Khorramabad, Iran, in 2015. The patients were divided into the 3 groups. 27 patients were classified statins consumption less than 6 days, 28 patients for 6 to 90 days, and 28 patients for more than 90 days. The level of sdLDL, lipid profile, TBARS and FRAP were assayed. RESULTS: FRAP levels of patients that received atorvastatin for more than 90 days (832 ± 101) were significantly elevated (P = 0.01) compared to the patients received atorvastatin less than 6 days (688 ± 75), whereas the levels of TBARS diminished significantly (P = 0.04). Also, the levels of total cholesterol (TC) and LDL-C were significantly decreased after 3 months of atorvastatin receiving (158 as compared to patients that consumed atorvastatin less than 6 days), (P = 0.02 and 0.03, respectively). The level of sdLDL was slightly increased with long-time consumption of atorvastatin (37 ± 14) in patients in comparison with patients that received atorvastatin less than 6 days (32 ± 15) (P = 0.06), but was not significant. CONCLUSION: The serum level of TBARS decreased and the serum level of FRAP increased in patients with long-time receiving atorvastatin. Therefore, atorvastatin contributes to the lowering oxidative stress in these patients. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2017-11 /pmc/articles/PMC5889919/ /pubmed/29643923 Text en © 2017 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Shahsavari, Gholamreza
Raoufi, Amir
Toolabi, Aram
Hosseninejadmir, Nahid
Ahmadvand, Hassan
Safariebrahimsarabie, Mehdi
The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title_full The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title_fullStr The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title_full_unstemmed The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title_short The effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: A case series study
title_sort effect of atorvastatin treatment duration on oxidative stress markers and lipid profile in patients with coronary artery diseases: a case series study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889919/
https://www.ncbi.nlm.nih.gov/pubmed/29643923
work_keys_str_mv AT shahsavarigholamreza theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT raoufiamir theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT toolabiaram theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT hosseninejadmirnahid theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT ahmadvandhassan theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT safariebrahimsarabiemehdi theeffectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT shahsavarigholamreza effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT raoufiamir effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT toolabiaram effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT hosseninejadmirnahid effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT ahmadvandhassan effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy
AT safariebrahimsarabiemehdi effectofatorvastatintreatmentdurationonoxidativestressmarkersandlipidprofileinpatientswithcoronaryarterydiseasesacaseseriesstudy