Cargando…
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cas...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890276/ https://www.ncbi.nlm.nih.gov/pubmed/29632299 http://dx.doi.org/10.1038/s41467-018-03178-z |
| _version_ | 1783312842735222784 |
|---|---|
| author | Vijayakrishnan, Jayaram Studd, James Broderick, Peter Kinnersley, Ben Holroyd, Amy Law, Philip J. Kumar, Rajiv Allan, James M. Harrison, Christine J. Moorman, Anthony V. Vora, Ajay Roman, Eve Rachakonda, Sivaramakrishna Kinsey, Sally E. Sheridan, Eamonn Thompson, Pamela D. Irving, Julie A. Koehler, Rolf Hoffmann, Per Nöthen, Markus M. Heilmann-Heimbach, Stefanie Jöckel, Karl-Heinz Easton, Douglas F. Pharaoh, Paul D. P. Dunning, Alison M. Peto, Julian Canzian, Frederico Swerdlow, Anthony Eeles, Rosalind A. Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Greaves, Mel Zimmerman, Martin Bartram, Claus R. Schrappe, Martin Stanulla, Martin Hemminki, Kari Houlston, Richard S. |
| author_facet | Vijayakrishnan, Jayaram Studd, James Broderick, Peter Kinnersley, Ben Holroyd, Amy Law, Philip J. Kumar, Rajiv Allan, James M. Harrison, Christine J. Moorman, Anthony V. Vora, Ajay Roman, Eve Rachakonda, Sivaramakrishna Kinsey, Sally E. Sheridan, Eamonn Thompson, Pamela D. Irving, Julie A. Koehler, Rolf Hoffmann, Per Nöthen, Markus M. Heilmann-Heimbach, Stefanie Jöckel, Karl-Heinz Easton, Douglas F. Pharaoh, Paul D. P. Dunning, Alison M. Peto, Julian Canzian, Frederico Swerdlow, Anthony Eeles, Rosalind A. Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Greaves, Mel Zimmerman, Martin Bartram, Claus R. Schrappe, Martin Stanulla, Martin Hemminki, Kari Houlston, Richard S. |
| author_sort | Vijayakrishnan, Jayaram |
| collection | PubMed |
| description | Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10(−9), odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10(−8), OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology. |
| format | Online Article Text |
| id | pubmed-5890276 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58902762018-04-11 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia Vijayakrishnan, Jayaram Studd, James Broderick, Peter Kinnersley, Ben Holroyd, Amy Law, Philip J. Kumar, Rajiv Allan, James M. Harrison, Christine J. Moorman, Anthony V. Vora, Ajay Roman, Eve Rachakonda, Sivaramakrishna Kinsey, Sally E. Sheridan, Eamonn Thompson, Pamela D. Irving, Julie A. Koehler, Rolf Hoffmann, Per Nöthen, Markus M. Heilmann-Heimbach, Stefanie Jöckel, Karl-Heinz Easton, Douglas F. Pharaoh, Paul D. P. Dunning, Alison M. Peto, Julian Canzian, Frederico Swerdlow, Anthony Eeles, Rosalind A. Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Greaves, Mel Zimmerman, Martin Bartram, Claus R. Schrappe, Martin Stanulla, Martin Hemminki, Kari Houlston, Richard S. Nat Commun Article Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10(−9), odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10(−8), OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology. Nature Publishing Group UK 2018-04-09 /pmc/articles/PMC5890276/ /pubmed/29632299 http://dx.doi.org/10.1038/s41467-018-03178-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Vijayakrishnan, Jayaram Studd, James Broderick, Peter Kinnersley, Ben Holroyd, Amy Law, Philip J. Kumar, Rajiv Allan, James M. Harrison, Christine J. Moorman, Anthony V. Vora, Ajay Roman, Eve Rachakonda, Sivaramakrishna Kinsey, Sally E. Sheridan, Eamonn Thompson, Pamela D. Irving, Julie A. Koehler, Rolf Hoffmann, Per Nöthen, Markus M. Heilmann-Heimbach, Stefanie Jöckel, Karl-Heinz Easton, Douglas F. Pharaoh, Paul D. P. Dunning, Alison M. Peto, Julian Canzian, Frederico Swerdlow, Anthony Eeles, Rosalind A. Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Greaves, Mel Zimmerman, Martin Bartram, Claus R. Schrappe, Martin Stanulla, Martin Hemminki, Kari Houlston, Richard S. Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_full | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_fullStr | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_full_unstemmed | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_short | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_sort | genome-wide association study identifies susceptibility loci for b-cell childhood acute lymphoblastic leukemia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890276/ https://www.ncbi.nlm.nih.gov/pubmed/29632299 http://dx.doi.org/10.1038/s41467-018-03178-z |
| work_keys_str_mv | AT vijayakrishnanjayaram genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT studdjames genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT broderickpeter genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT kinnersleyben genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT holroydamy genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT lawphilipj genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT kumarrajiv genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT allanjamesm genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT harrisonchristinej genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT moormananthonyv genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT voraajay genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT romaneve genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT rachakondasivaramakrishna genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT kinseysallye genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT sheridaneamonn genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT thompsonpamelad genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT irvingjuliea genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT koehlerrolf genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT hoffmannper genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT nothenmarkusm genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT heilmannheimbachstefanie genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT jockelkarlheinz genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT eastondouglasf genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT pharaohpauldp genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT dunningalisonm genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT petojulian genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT canzianfrederico genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT swerdlowanthony genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT eelesrosalinda genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT kotejaraizsofia genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT muirkenneth genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT pashayannora genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT greavesmel genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT zimmermanmartin genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT bartramclausr genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT schrappemartin genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT stanullamartin genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT hemminkikari genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia AT houlstonrichards genomewideassociationstudyidentifiessusceptibilitylociforbcellchildhoodacutelymphoblasticleukemia |