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Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells

Clinical and fundamental research suggest that altered calcium and cAMP signaling might be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a reduced resting cytosolic calcium [Ca(2+)](i) and increased cAMP levels. CaSR plays an essential role in regulating calcium homeost...

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Detalles Bibliográficos
Autores principales:	Di Mise, Annarita, Tamma, Grazia, Ranieri, Marianna, Centrone, Mariangela, van den Heuvel, Lambertus, Mekahli, Djalila, Levtchenko, Elena N., Valenti, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890283/ https://www.ncbi.nlm.nih.gov/pubmed/29632324 http://dx.doi.org/10.1038/s41598-018-23732-5

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