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The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model
BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the pat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society for Plastic Surgeons
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890365/ https://www.ncbi.nlm.nih.gov/pubmed/29651391 |
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author | Mahboubi, Mohaddese Taghizadeh, Mohsen Khamechian, Tahereh Tamtaji, Omid Reza Mokhtari, Rasoul Talaei, Sayyed Alireza |
author_facet | Mahboubi, Mohaddese Taghizadeh, Mohsen Khamechian, Tahereh Tamtaji, Omid Reza Mokhtari, Rasoul Talaei, Sayyed Alireza |
author_sort | Mahboubi, Mohaddese |
collection | PubMed |
description | BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS: The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically. RESULTS: Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models. CONCLUSION: Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs. |
format | Online Article Text |
id | pubmed-5890365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Iranian Society for Plastic Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-58903652018-04-12 The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model Mahboubi, Mohaddese Taghizadeh, Mohsen Khamechian, Tahereh Tamtaji, Omid Reza Mokhtari, Rasoul Talaei, Sayyed Alireza World J Plast Surg Original Article BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS: The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically. RESULTS: Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models. CONCLUSION: Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs. Iranian Society for Plastic Surgeons 2018-01 /pmc/articles/PMC5890365/ /pubmed/29651391 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mahboubi, Mohaddese Taghizadeh, Mohsen Khamechian, Tahereh Tamtaji, Omid Reza Mokhtari, Rasoul Talaei, Sayyed Alireza The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title | The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title_full | The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title_fullStr | The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title_full_unstemmed | The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title_short | The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model |
title_sort | wound healing effects of herbal cream containing oliveria decumbens and pelargonium graveolens essential oils in diabetic foot ulcer model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890365/ https://www.ncbi.nlm.nih.gov/pubmed/29651391 |
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