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Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis

A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs h...

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Detalles Bibliográficos
Autores principales: Salviano-Silva, Amanda, Lobo-Alves, Sara Cristina, de Almeida, Rodrigo Coutinho, Malheiros, Danielle, Petzl-Erler, Maria Luiza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890390/
https://www.ncbi.nlm.nih.gov/pubmed/29657300
http://dx.doi.org/10.3390/ncrna4010003
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author Salviano-Silva, Amanda
Lobo-Alves, Sara Cristina
de Almeida, Rodrigo Coutinho
Malheiros, Danielle
Petzl-Erler, Maria Luiza
author_facet Salviano-Silva, Amanda
Lobo-Alves, Sara Cristina
de Almeida, Rodrigo Coutinho
Malheiros, Danielle
Petzl-Erler, Maria Luiza
author_sort Salviano-Silva, Amanda
collection PubMed
description A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs has produced a major shift in our understanding of gene and genome regulation and structure. It became apparent that lncRNAs regulate gene expression through several mechanisms. These RNAs function as transcriptional or post-transcriptional regulators through binding to histone-modifying complexes, to DNA, to transcription factors and other DNA binding proteins, to RNA polymerase II, to mRNA, or through the modulation of microRNA or enzyme function. Often, the lncRNA transcription itself rather than the lncRNA product appears to be regulatory. In this review, we highlight studies identifying lncRNAs in the homeostasis of various cell and tissue types or demonstrating their effects in the expression of protein-coding or other non-coding RNA genes.
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spelling pubmed-58903902018-04-12 Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis Salviano-Silva, Amanda Lobo-Alves, Sara Cristina de Almeida, Rodrigo Coutinho Malheiros, Danielle Petzl-Erler, Maria Luiza Noncoding RNA Review A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs has produced a major shift in our understanding of gene and genome regulation and structure. It became apparent that lncRNAs regulate gene expression through several mechanisms. These RNAs function as transcriptional or post-transcriptional regulators through binding to histone-modifying complexes, to DNA, to transcription factors and other DNA binding proteins, to RNA polymerase II, to mRNA, or through the modulation of microRNA or enzyme function. Often, the lncRNA transcription itself rather than the lncRNA product appears to be regulatory. In this review, we highlight studies identifying lncRNAs in the homeostasis of various cell and tissue types or demonstrating their effects in the expression of protein-coding or other non-coding RNA genes. MDPI 2018-01-30 /pmc/articles/PMC5890390/ /pubmed/29657300 http://dx.doi.org/10.3390/ncrna4010003 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salviano-Silva, Amanda
Lobo-Alves, Sara Cristina
de Almeida, Rodrigo Coutinho
Malheiros, Danielle
Petzl-Erler, Maria Luiza
Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title_full Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title_fullStr Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title_full_unstemmed Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title_short Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis
title_sort besides pathology: long non-coding rna in cell and tissue homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890390/
https://www.ncbi.nlm.nih.gov/pubmed/29657300
http://dx.doi.org/10.3390/ncrna4010003
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