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Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities

Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, induces hepatic injury in human hepatocytes through dysregulat...

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Detalles Bibliográficos
Autores principales: Masson, Jesse JR, Billings, Hugh WW, Palmer, Clovis S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890528/
https://www.ncbi.nlm.nih.gov/pubmed/28768434
http://dx.doi.org/10.1177/2040206617701372
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author Masson, Jesse JR
Billings, Hugh WW
Palmer, Clovis S
author_facet Masson, Jesse JR
Billings, Hugh WW
Palmer, Clovis S
author_sort Masson, Jesse JR
collection PubMed
description Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, induces hepatic injury in human hepatocytes through dysregulation of aerobic glycolysis and lipid metabolism. Increased glycolytic metabolism mediated by elevated expression of Glut1, glucose influx, and lactate secretion is associated with this Warburg phenotype, a classic metabolic signature also observed in cancer cells. This article brings into focus the tight interaction between HBV infection and metabolic dysfunction and how these processes facilitate the progression of end-stage liver diseases, such as hepatocellular carcinoma. We also provide evidence and models by which other viruses such as HIV and Zika disrupt their host metabolic machinery. The emergence of the immunometabolism field provides novel opportunities to take advantage of intermediary metabolites and key metabolic pathways for diagnostic and therapeutic purposes.
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spelling pubmed-58905282018-04-17 Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities Masson, Jesse JR Billings, Hugh WW Palmer, Clovis S Antivir Chem Chemother Reviews Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, induces hepatic injury in human hepatocytes through dysregulation of aerobic glycolysis and lipid metabolism. Increased glycolytic metabolism mediated by elevated expression of Glut1, glucose influx, and lactate secretion is associated with this Warburg phenotype, a classic metabolic signature also observed in cancer cells. This article brings into focus the tight interaction between HBV infection and metabolic dysfunction and how these processes facilitate the progression of end-stage liver diseases, such as hepatocellular carcinoma. We also provide evidence and models by which other viruses such as HIV and Zika disrupt their host metabolic machinery. The emergence of the immunometabolism field provides novel opportunities to take advantage of intermediary metabolites and key metabolic pathways for diagnostic and therapeutic purposes. SAGE Publications 2017-08-03 2017-08 /pmc/articles/PMC5890528/ /pubmed/28768434 http://dx.doi.org/10.1177/2040206617701372 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Masson, Jesse JR
Billings, Hugh WW
Palmer, Clovis S
Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title_full Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title_fullStr Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title_full_unstemmed Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title_short Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities
title_sort metabolic reprogramming during hepatitis b disease progression offers novel diagnostic and therapeutic opportunities
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890528/
https://www.ncbi.nlm.nih.gov/pubmed/28768434
http://dx.doi.org/10.1177/2040206617701372
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