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Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses. High antiviral potency and favorable pharmacokinetics parameters make some nucleosid...

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Autores principales: Eyer, Luděk, Nencka, Radim, de Clercq, Erik, Seley-Radtke, Katherine, Růžek, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890575/
https://www.ncbi.nlm.nih.gov/pubmed/29534608
http://dx.doi.org/10.1177/2040206618761299
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author Eyer, Luděk
Nencka, Radim
de Clercq, Erik
Seley-Radtke, Katherine
Růžek, Daniel
author_facet Eyer, Luděk
Nencka, Radim
de Clercq, Erik
Seley-Radtke, Katherine
Růžek, Daniel
author_sort Eyer, Luděk
collection PubMed
description Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses. High antiviral potency and favorable pharmacokinetics parameters make some nucleoside analogs suitable also for the treatment of acute infections caused by other medically important RNA and DNA viruses. This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase. Inhibitors of intracellular nucleoside synthesis and newly discovered nucleoside derivatives with high antiflavivirus potency, whose modes of action are currently not completely understood, have drawn attention. Moreover, this review highlights important challenges and complications in nucleoside analog development and suggests possible strategies to overcome these limitations.
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spelling pubmed-58905752018-04-17 Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses Eyer, Luděk Nencka, Radim de Clercq, Erik Seley-Radtke, Katherine Růžek, Daniel Antivir Chem Chemother SI: Advances in Antiviral Nucleoside Analogs and Their Prodrugs Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses. High antiviral potency and favorable pharmacokinetics parameters make some nucleoside analogs suitable also for the treatment of acute infections caused by other medically important RNA and DNA viruses. This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase. Inhibitors of intracellular nucleoside synthesis and newly discovered nucleoside derivatives with high antiflavivirus potency, whose modes of action are currently not completely understood, have drawn attention. Moreover, this review highlights important challenges and complications in nucleoside analog development and suggests possible strategies to overcome these limitations. SAGE Publications 2018-03-13 /pmc/articles/PMC5890575/ /pubmed/29534608 http://dx.doi.org/10.1177/2040206618761299 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle SI: Advances in Antiviral Nucleoside Analogs and Their Prodrugs
Eyer, Luděk
Nencka, Radim
de Clercq, Erik
Seley-Radtke, Katherine
Růžek, Daniel
Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title_full Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title_fullStr Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title_full_unstemmed Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title_short Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
title_sort nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
topic SI: Advances in Antiviral Nucleoside Analogs and Their Prodrugs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890575/
https://www.ncbi.nlm.nih.gov/pubmed/29534608
http://dx.doi.org/10.1177/2040206618761299
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