Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors

OBJECTIVES: To characterise the clinical features, immune manifestations and molecular mechanisms in a recently described autoinflammatory disease caused by mutations in TRNT1, a tRNA processing enzyme, and to explore the use of cytokine inhibitors in suppressing the inflammatory phenotype. METHODS:...

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Detalles Bibliográficos
Autores principales: Giannelou, Angeliki, Wang, Hongying, Zhou, Qing, Park, Yong Hwan, Abu-Asab, Mones S, Ylaya, Kris, Stone, Deborah L, Sediva, Anna, Sleiman, Rola, Sramkova, Lucie, Bhatla, Deepika, Serti, Elisavet, Tsai, Wanxia Li, Yang, Dan, Bishop, Kevin, Carrington, Blake, Pei, Wuhong, Deuitch, Natalie, Brooks, Stephen, Edwan, Jehad H, Joshi, Sarita, Prader, Seraina, Kaiser, Daniela, Owen, William C, Sonbul, Abdullah Al, Zhang, Yu, Niemela, Julie E, Burgess, Shawn M, Boehm, Manfred, Rehermann, Barbara, Chae, JaeJin, Quezado, Martha M, Ombrello, Amanda K, Buckley, Rebecca H, Grom, Alexi A, Remmers, Elaine F, Pachlopnik, Jana M, Su, Helen C, Gutierrez-Cruz, Gustavo, Hewitt, Stephen M, Sood, Raman, Risma, Kimberly, Calvo, Katherine R, Rosenzweig, Sergio D, Gadina, Massimo, Hafner, Markus, Sun, Hong-Wei, Kastner, Daniel L, Aksentijevich, Ivona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890629/
https://www.ncbi.nlm.nih.gov/pubmed/29358286
http://dx.doi.org/10.1136/annrheumdis-2017-212401

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