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Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

BACKGROUND: Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA gyrase and topoisomerase IV from inhibition by fluoroquinolones, contribute to resistance development. However, the pres...

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Detalles Bibliográficos
Autores principales:	Garoff, Linnéa, Yadav, Kavita, Hughes, Diarmaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890660/ https://www.ncbi.nlm.nih.gov/pubmed/29106520 http://dx.doi.org/10.1093/jac/dkx375

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