Delivering precision antimicrobial therapy through closed-loop control systems

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true indivi...

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Autores principales: Rawson, T M, O’Hare, D, Herrero, P, Sharma, S, Moore, L S P, de Barra, E, Roberts, J A, Gordon, A C, Hope, W, Georgiou, P, Cass, A E G, Holmes, A H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890674/
https://www.ncbi.nlm.nih.gov/pubmed/29211877
http://dx.doi.org/10.1093/jac/dkx458
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author Rawson, T M
O’Hare, D
Herrero, P
Sharma, S
Moore, L S P
de Barra, E
Roberts, J A
Gordon, A C
Hope, W
Georgiou, P
Cass, A E G
Holmes, A H
author_facet Rawson, T M
O’Hare, D
Herrero, P
Sharma, S
Moore, L S P
de Barra, E
Roberts, J A
Gordon, A C
Hope, W
Georgiou, P
Cass, A E G
Holmes, A H
author_sort Rawson, T M
collection PubMed
description Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.
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spelling pubmed-58906742018-04-13 Delivering precision antimicrobial therapy through closed-loop control systems Rawson, T M O’Hare, D Herrero, P Sharma, S Moore, L S P de Barra, E Roberts, J A Gordon, A C Hope, W Georgiou, P Cass, A E G Holmes, A H J Antimicrob Chemother Review Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients. Oxford University Press 2018-04 2017-12-04 /pmc/articles/PMC5890674/ /pubmed/29211877 http://dx.doi.org/10.1093/jac/dkx458 Text en © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rawson, T M
O’Hare, D
Herrero, P
Sharma, S
Moore, L S P
de Barra, E
Roberts, J A
Gordon, A C
Hope, W
Georgiou, P
Cass, A E G
Holmes, A H
Delivering precision antimicrobial therapy through closed-loop control systems
title Delivering precision antimicrobial therapy through closed-loop control systems
title_full Delivering precision antimicrobial therapy through closed-loop control systems
title_fullStr Delivering precision antimicrobial therapy through closed-loop control systems
title_full_unstemmed Delivering precision antimicrobial therapy through closed-loop control systems
title_short Delivering precision antimicrobial therapy through closed-loop control systems
title_sort delivering precision antimicrobial therapy through closed-loop control systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890674/
https://www.ncbi.nlm.nih.gov/pubmed/29211877
http://dx.doi.org/10.1093/jac/dkx458
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