Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin

OBJECTIVES: To establish the role of specific, non-synonymous SNPs in the RNA polymerase β subunit (rpoB) gene in reducing the susceptibility of Clostridium difficile to fidaxomicin and to explore the potential in vivo significance of rpoB mutant strains. METHODS: Allelic exchange was used to introd...

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Detalles Bibliográficos
Autores principales: Kuehne, Sarah A, Dempster, Andrew W, Collery, Mark M, Joshi, Nimitray, Jowett, Jamie, Kelly, Michelle L, Cave, Rory, Longshaw, Chris M, Minton, Nigel P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890677/
https://www.ncbi.nlm.nih.gov/pubmed/29253242
http://dx.doi.org/10.1093/jac/dkx486

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