Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study

BACKGROUND: Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. OBJECTIVES: To describe the pharmacokinetics and establish a pharmacokinetic/pharmacodynamic relationship for miltefosine in Eastern African patients with visceral leishmaniasi...

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Detalles Bibliográficos
Autores principales: Dorlo, Thomas P C, Kip, Anke E, Younis, Brima M, Ellis, Sally J, Alves, Fabiana, Beijnen, Jos. H, Njenga, Simon, Kirigi, George, Hailu, Asrat, Olobo, Joseph, Musa, Ahmed M, Balasegaram, Manica, Wasunna, Monique, Karlsson, Mats O, Khalil, Eltahir A G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890687/
https://www.ncbi.nlm.nih.gov/pubmed/28961737
http://dx.doi.org/10.1093/jac/dkx283

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