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Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
OBJECTIVES: To determine whether the spectrum of mutations in marR in ciprofloxacin-resistant clinical isolates of Escherichia coli shows evidence of selection bias, either to reduce fitness costs, or to increase drug resistance. MarR is a repressor protein that regulates, via MarA, expression of th...
Autores principales: | Praski Alzrigat, Lisa, Huseby, Douglas L, Brandis, Gerrit, Hughes, Diarmaid |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890708/ https://www.ncbi.nlm.nih.gov/pubmed/28962020 http://dx.doi.org/10.1093/jac/dkx270 |
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