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Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
A [(i–Pr)PDI]CoBr(2) complex (PDI = pyridine-diimine) catalyzes Simmons–Smith-type reductive cyclopropanation reactions using CH(2)Br(2) in combination with Zn. In contrast to its non-catalytic variant, the cobalt-catalyzed cyclopropanation is capable of discriminating between alkenes of similar ele...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890799/ https://www.ncbi.nlm.nih.gov/pubmed/29675205 http://dx.doi.org/10.1039/c7sc04861k |
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author | Werth, Jacob Uyeda, Christopher |
author_facet | Werth, Jacob Uyeda, Christopher |
author_sort | Werth, Jacob |
collection | PubMed |
description | A [(i–Pr)PDI]CoBr(2) complex (PDI = pyridine-diimine) catalyzes Simmons–Smith-type reductive cyclopropanation reactions using CH(2)Br(2) in combination with Zn. In contrast to its non-catalytic variant, the cobalt-catalyzed cyclopropanation is capable of discriminating between alkenes of similar electronic properties based on their substitution patterns: monosubstituted > 1,1-disubstituted > (Z)-1,2-disubstituted > (E)-1,2-disubstituted > trisubstituted. This property enables synthetically useful yields to be achieved for the monocyclopropanation of polyalkene substrates, including terpene derivatives and conjugated 1,3-dienes. Mechanistic studies implicate a carbenoid species containing both Co and Zn as the catalytically relevant methylene transfer agent. |
format | Online Article Text |
id | pubmed-5890799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-58907992018-04-19 Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis Werth, Jacob Uyeda, Christopher Chem Sci Chemistry A [(i–Pr)PDI]CoBr(2) complex (PDI = pyridine-diimine) catalyzes Simmons–Smith-type reductive cyclopropanation reactions using CH(2)Br(2) in combination with Zn. In contrast to its non-catalytic variant, the cobalt-catalyzed cyclopropanation is capable of discriminating between alkenes of similar electronic properties based on their substitution patterns: monosubstituted > 1,1-disubstituted > (Z)-1,2-disubstituted > (E)-1,2-disubstituted > trisubstituted. This property enables synthetically useful yields to be achieved for the monocyclopropanation of polyalkene substrates, including terpene derivatives and conjugated 1,3-dienes. Mechanistic studies implicate a carbenoid species containing both Co and Zn as the catalytically relevant methylene transfer agent. Royal Society of Chemistry 2018-01-02 /pmc/articles/PMC5890799/ /pubmed/29675205 http://dx.doi.org/10.1039/c7sc04861k Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Werth, Jacob Uyeda, Christopher Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis |
title | Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
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title_full | Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
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title_fullStr | Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
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title_full_unstemmed | Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
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title_short | Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis
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title_sort | regioselective simmons–smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890799/ https://www.ncbi.nlm.nih.gov/pubmed/29675205 http://dx.doi.org/10.1039/c7sc04861k |
work_keys_str_mv | AT werthjacob regioselectivesimmonssmithtypecyclopropanationsofpolyalkenesenabledbytransitionmetalcatalysis AT uyedachristopher regioselectivesimmonssmithtypecyclopropanationsofpolyalkenesenabledbytransitionmetalcatalysis |