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Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in various immunological diseases. Foxp3 (Forkhead box P3) expression in iTregs is, however, unstable due to the lack of demethyl...

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Detalles Bibliográficos
Autores principales:	Someya, Kazue, Nakatsukasa, Hiroko, Ito, Minako, Kondo, Taisuke, Tateda, Kenn-ichi, Akanuma, Takashi, Koya, Ikuko, Sanosaka, Tsukasa, Kohyama, Jun, Tsukada, Yu-ichi, Takamura-Enya, Takeji, Yoshimura, Akihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Featured Article of the Month
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890887/ https://www.ncbi.nlm.nih.gov/pubmed/29048538 http://dx.doi.org/10.1093/intimm/dxx049

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